Literature DB >> 15186765

Translesion DNA synthesis: little fingers teach tolerance.

Oliver Fleck1, Primo Schär.   

Abstract

DNA synthesis on a damaged template requires tolerant DNA polymerases. Crystallographic analysis has captured a Y-family polymerase synthesizing across an abasic site, providing insight into the mechanisms of DNA damage tolerance and mutation.

Mesh：

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Year:  2004        PMID： 15186765     DOI： 10.1016/j.cub.2004.05.014

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  10 in total

1.  Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass.

Authors:  Yanli Wang; Karunesh Arora; Tamar Schlick
Journal:  Protein Sci       Date:  2005-12-01       Impact factor: 6.725

2.  DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.

Authors:  Gang Liu; Xinbin Chen
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

3.  Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.

Authors:  Ryan D Bomgarden; Patrick J Lupardus; Deena V Soni; Muh-Ching Yee; James M Ford; Karlene A Cimprich
Journal:  EMBO J       Date:  2006-05-04       Impact factor: 11.598

Review 4.  Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice.

Authors:  Gemma Bellí; Neus Colomina; Laia Castells-Roca; Neus P Lorite
Journal:  J Fungi (Basel)       Date:  2022-06-10

5.  Investigation of Intradomain Motions of a Y-Family DNA Polymerase during Substrate Binding and Catalysis.

Authors:  Austin T Raper; Zucai Suo
Journal:  Biochemistry       Date:  2016-10-10       Impact factor: 3.162

Review 6.  Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer.

Authors:  Anthony J Berdis
Journal:  Front Mol Biosci       Date:  2017-11-21

7.  Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations.

Authors:  Pramodha S Liyanage; Alice R Walker; Alfonso Brenlla; G Andrés Cisneros; Louis J Romano; David Rueda
Journal:  Sci Rep       Date:  2017-12-12       Impact factor: 4.379

8.  Investigating the Conformational Dynamics of a Y-Family DNA Polymerase during Its Folding and Binding to DNA and a Nucleotide.

Authors:  Xiakun Chu; Zucai Suo; Jin Wang
Journal:  JACS Au       Date:  2021-12-16

Review 9.  Mechanisms for Maintaining Eukaryotic Replisome Progression in the Presence of DNA Damage.

Authors:  Thomas A Guilliam
Journal:  Front Mol Biosci       Date:  2021-07-06

10.  Base excision repair intermediates are mutagenic in mammalian cells.

Authors:  Valeria Simonelli; Laura Narciso; Eugenia Dogliotti; Paola Fortini
Journal:  Nucleic Acids Res       Date:  2005-08-02       Impact factor: 16.971
  10 in total

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