| Literature DB >> 15186258 |
Stuart P Berzins1, Adam P Uldrich, Daniel G Pellicci, Finlay McNab, Yoshihiro Hayakawa, Mark J Smyth, Dale I Godfrey.
Abstract
NKT cells are emerging as an extremely influential regulatory subset of T lymphocytes that are functionally and developmentally distinct from their mainstream counterparts. Like other T cells, NKT cells are thymus-dependent but their apparently unique pathway of differentiation is poorly characterized. Given the strong association between NKT cell deficiency and increased incidences of autoimmunity and cancer it is imperative that the mechanisms by which NKT cells are generated becomes better understood. This review examines what is known about NKT cell development in the thymus and highlights elements of the pathway that differ significantly from mainstream T-cell development. It is here that NKT cell-specific disorders may originate and may best be addressed.Entities:
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Year: 2004 PMID： 15186258 DOI： 10.1111/j.0818-9641.2004.01256.x
Source DB: PubMed Journal: Immunol Cell Biol ISSN： 0818-9641 Impact factor: 5.126