Jianguo Huang1, Guiming Li, Jihu Xiang, Daochun Yin, Ridong Chi. 1. Department of Dermatology, People's Hospital of Xiangxi Autonomous Prefecture (the First Affiliated Hospital of Ji-shou University), Ji-shou City, Hunan Province, China. huangjianguo11@sina.com
Abstract
OBJECTIVE: To study the role of serotonin in the pathogenesis of psoriasis. METHODS: Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with psoriasis. RESULTS: Expression of serotonin was significantly stronger in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in the progressive stage of psoriasis than in the static stage. There was no difference in serotonin expression between the vulgaris type and the pustular type. No expression of serotonin occurred in the specimens of normal skin. CONCLUSION: Serotonin probably plays an important role in the pathogenesis and activity of psoriasis.
OBJECTIVE: To study the role of serotonin in the pathogenesis of psoriasis. METHODS: Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with psoriasis. RESULTS: Expression of serotonin was significantly stronger in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in the progressive stage of psoriasis than in the static stage. There was no difference in serotonin expression between the vulgaris type and the pustular type. No expression of serotonin occurred in the specimens of normal skin. CONCLUSION:Serotonin probably plays an important role in the pathogenesis and activity of psoriasis.
Authors: Kent Sakai; Kristen M Sanders; Marina R Youssef; Kevin M Yanushefski; Liselotte Jensen; Gil Yosipovitch; Tasuku Akiyama Journal: Pain Date: 2016-11 Impact factor: 7.926