Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 New rapamycin derivatives by precursor-directed biosynthesis.

Literature DB >> 15185378

New rapamycin derivatives by precursor-directed biosynthesis.

Philip A S Lowden¹, Günter A Böhm, Su Metcalfe, James Staunton, Peter F Leadlay.

Abstract

Mesh：

Substances：

Year: 2004 PMID： 15185378 DOI： 10.1002/cbic.200300758

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

Keyword Cloud
Cited

× No keyword cloud information.

8 in total

1. Production of novel rapamycin analogs by precursor-directed biosynthesis.

Authors: Frank V Ritacco; Edmund I Graziani; Mia Y Summers; T Mark Zabriskie; Ker Yu; Valerie S Bernan; Guy T Carter; Michael Greenstein
Journal: Appl Environ Microbiol Date: 2005-04 Impact factor: 4.792

2. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Authors: Jennifer N Andexer; Steven G Kendrew; Mohammad Nur-e-Alam; Orestis Lazos; Teresa A Foster; Anna-Sophie Zimmermann; Tony D Warneck; Dipen Suthar; Nigel J Coates; Frank E Koehn; Jerauld S Skotnicki; Guy T Carter; Matthew A Gregory; Christine J Martin; Steven J Moss; Peter F Leadlay; Barrie Wilkinson
Journal: Proc Natl Acad Sci U S A Date: 2011-03-07 Impact factor: 11.205

Review 3. An overview of rapamycin: from discovery to future perspectives.

Authors: Young Ji Yoo; Hanseong Kim; Sung Ryeol Park; Yeo Joon Yoon
Journal: J Ind Microbiol Biotechnol Date: 2016-09-09 Impact factor: 3.346

4. An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35.

Authors: Tina Netzker; Volker Schroeckh; Matthew A Gregory; Michal Flak; Mario K C Krespach; Peter F Leadlay; Axel A Brakhage
Journal: Appl Environ Microbiol Date: 2016-05-31 Impact factor: 4.792

New rapamycin derivatives by precursor-directed biosynthesis.

1. Production of novel rapamycin analogs by precursor-directed biosynthesis.

2. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Review 3. An overview of rapamycin: from discovery to future perspectives.

4. An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35.

5. Improved precursor-directed biosynthesis in E. coli via directed evolution.

Review 6. Engineered polyketides: Synergy between protein and host level engineering.

7. Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase.

8. Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis.