L Schmitz1, A Xanthopoulos, H Koch, P E Lange. 1. Department of Pediatric Cardiology, Charité Medical Center, Humboldt-University of Berlin, Augustenburger Platz 1, D-13353, Berlin, Germany. lothar.schmitz@berlin.de
Abstract
OBJECTIVE: To study the impact of the maturational process of diastolic left ventricular function on trans-mitral Doppler flow parameters. METHODS AND PARTICIPANTS: In a survey we examined pulsed-wave Doppler signals and diastolic time intervals from 238 healthy neonates and infants. Using multiple linear regression analysis, we evaluated the impact of physiological determinants on parameter expression. RESULTS: Early-filling and atrial-filling peak velocities, early-filling acceleration and deceleration rates, and the atrial-filling time velocity integral reached a climax within 2 months after birth, while early-filling time velocity integral followed increasing throughout the study period. The isovolumic relaxation time was found to be significantly longer for neonates than for infants older than 2 months. The observed parameter movements could be attributed to changes of stroke volume and mitral valve area for early filling-time velocity integral (R2 = 0.93), and of heart rate, stroke volume, and mitral valve area for early filling peak velocity (R2 = 0.84), and atrial-filling time velocity integral (R2 = 0.65). Isovolumic relaxation time and atrial-filling peak velocity became heart rate dependent not before 3 months after birth. CONCLUSIONS: The observed parameter changes are powerful indicators for the maturational process in diastolic function. This process is mainly completed by 3 months of age.
OBJECTIVE: To study the impact of the maturational process of diastolic left ventricular function on trans-mitral Doppler flow parameters. METHODS AND PARTICIPANTS: In a survey we examined pulsed-wave Doppler signals and diastolic time intervals from 238 healthy neonates and infants. Using multiple linear regression analysis, we evaluated the impact of physiological determinants on parameter expression. RESULTS: Early-filling and atrial-filling peak velocities, early-filling acceleration and deceleration rates, and the atrial-filling time velocity integral reached a climax within 2 months after birth, while early-filling time velocity integral followed increasing throughout the study period. The isovolumic relaxation time was found to be significantly longer for neonates than for infants older than 2 months. The observed parameter movements could be attributed to changes of stroke volume and mitral valve area for early filling-time velocity integral (R2 = 0.93), and of heart rate, stroke volume, and mitral valve area for early filling peak velocity (R2 = 0.84), and atrial-filling time velocity integral (R2 = 0.65). Isovolumic relaxation time and atrial-filling peak velocity became heart rate dependent not before 3 months after birth. CONCLUSIONS: The observed parameter changes are powerful indicators for the maturational process in diastolic function. This process is mainly completed by 3 months of age.
Authors: Yuichiro Z Sato; Delaram P Molkara; Lori B Daniels; Adriana H Tremoulet; Chisato Shimizu; John T Kanegaye; Brookie M Best; James V Snider; Jeffrey R Frazer; Alan Maisel; Jane C Burns Journal: Int J Cardiol Date: 2011-07-20 Impact factor: 4.164
Authors: John T Kanegaye; Matthew S Wilder; Delaram Molkara; Jeffrey R Frazer; Joan Pancheri; Adriana H Tremoulet; Virginia E Watson; Brookie M Best; Jane C Burns Journal: Pediatrics Date: 2009-05 Impact factor: 7.124