BACKGROUND: Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable risk factors. This study investigates risk related to dietary factors, which are potentially modifiable. METHODS: Newly diagnosed patients with melanoma (n = 502) were recruited from pigment lesion clinics and controls (n = 565) were recruited from outpatient clinics. To investigate the relationship between melanoma and dietary factors in this case-control study, study subjects were requested to complete a food frequency questionnaire, which assessed diet over the previous year. Using logistic regression, odds ratios (ORs) for melanoma were computed for nutrient and alcohol intake. RESULTS: Persons in high versus low quintiles of energy-adjusted vitamin D, alpha-carotene, beta-carotene, cryptoxanthin, lutein, and lycopene had significantly reduced risk for melanoma (ORs < or = 0.67), which remained after adjustment for presence of dysplastic nevi, education, and skin response to repeated sun exposure. Addition of micronutrients from supplements did not add an additional reduction in risk. High alcohol consumption was associated with an increased risk for melanoma, which remained after adjustment for confounders [OR (95% confidence interval) in highest versus lowest quintiles, 1.65 (1.09-2.49)]. CONCLUSIONS: Diets consisting of foods rich in vitamin D and carotenoids and low in alcohol may be associated with a reduction in risk for melanoma. These analyses should be repeated in large, prospective studies.
BACKGROUND:Malignant melanoma has been one of the most rapidly increasing cancers within the United States with few modifiable risk factors. This study investigates risk related to dietary factors, which are potentially modifiable. METHODS: Newly diagnosed patients with melanoma (n = 502) were recruited from pigment lesion clinics and controls (n = 565) were recruited from outpatient clinics. To investigate the relationship between melanoma and dietary factors in this case-control study, study subjects were requested to complete a food frequency questionnaire, which assessed diet over the previous year. Using logistic regression, odds ratios (ORs) for melanoma were computed for nutrient and alcohol intake. RESULTS:Persons in high versus low quintiles of energy-adjusted vitamin D, alpha-carotene, beta-carotene, cryptoxanthin, lutein, and lycopene had significantly reduced risk for melanoma (ORs < or = 0.67), which remained after adjustment for presence of dysplastic nevi, education, and skin response to repeated sun exposure. Addition of micronutrients from supplements did not add an additional reduction in risk. High alcohol consumption was associated with an increased risk for melanoma, which remained after adjustment for confounders [OR (95% confidence interval) in highest versus lowest quintiles, 1.65 (1.09-2.49)]. CONCLUSIONS: Diets consisting of foods rich in vitamin D and carotenoids and low in alcohol may be associated with a reduction in risk for melanoma. These analyses should be repeated in large, prospective studies.
Authors: Rochelle Mandelcorn-Monson; Loraine Marrett; Anne Kricker; Bruce K Armstrong; Irene Orlow; Chris Goumas; Susan Paine; Stefano Rosso; Nancy Thomas; Robert C Millikan; Jason D Pole; Javier Cotignola; Cheryl Rosen; Peter A Kanetsky; Julia Lee-Taylor; Colin B Begg; Marianne Berwick Journal: Cancer Epidemiol Date: 2011-05-25 Impact factor: 2.984
Authors: Yao-Ping Lu; You-Rong Lou; Bonnie Nolan; Qing-Yun Peng; Jian-Guo Xie; George C Wagner; Allan H Conney Journal: Proc Natl Acad Sci U S A Date: 2006-10-23 Impact factor: 11.205
Authors: Jean Y Tang; Teresa Fu; Erin Leblanc; Joann E Manson; David Feldman; Eleni Linos; Mara Z Vitolins; Nathalie C Zeitouni; Joseph Larson; Marcia L Stefanick Journal: J Clin Oncol Date: 2011-06-27 Impact factor: 44.544
Authors: Miguel Rivas; Elisa Rojas; Gloria M Calaf; Marcela Barberán; Claudio Liberman; Marcelo De Paula Correa Journal: Oncol Lett Date: 2017-03-23 Impact factor: 2.967
Authors: Jean Y Tang; Teresa Fu; Christopher Lau; Dennis H Oh; Daniel D Bikle; Maryam M Asgari Journal: J Am Acad Dermatol Date: 2012-11 Impact factor: 11.527