| Literature DB >> 15183913 |
Annie Mayence1, Jean Jacques Vanden Eynde, Louis LeCour, Larry A Walker, Babu L Tekwani, Tien L Huang.
Abstract
A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC(50) value of 0.41 microM which is about sevenfold more potent than pentamidine.Entities:
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Year: 2004 PMID： 15183913 DOI： 10.1016/j.ejmech.2004.01.009
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514