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Literature DB >> 15183655

Neonatal neutrophils: the good, the bad, and the ugly.

Abstract

Neonates are at considerable risk for bacterial and fungal infections,due in great part to a variety of age-related impairments in neutrophil function. In addition, evidence suggests that the tendency of the most immature neonates to develop chronic inflammatory disorders is also related to neutrophil dysfunction. This article provides an overview of specific functional deficiencies of neutrophils that have been reported in neonates.

Entities: Disease

Mesh：

Year: 2004 PMID： 15183655 DOI： 10.1016/j.clp.2004.03.013

Source DB: PubMed Journal: Clin Perinatol ISSN： 0095-5108 Impact factor: 3.430

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Cited

19 in total

1. Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants.

Authors: Nathan L Thornton; Mark J Cody; Christian C Yost
Journal: Neonatology Date: 2011-09-23 Impact factor: 4.035

2. Murine neonates are highly resistant to Yersinia enterocolitica following orogastric exposure.

Authors: Andrea Echeverry; Kurt Schesser; Becky Adkins
Journal: Infect Immun Date: 2007-02-26 Impact factor: 3.441

3. Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4.

Authors: Barry Weinberger; Cecile Quizon; Anna M Vetrano; Faith Archer; Jeffrey D Laskin; Debra L Laskin
Journal: Pediatr Res Date: 2008-10 Impact factor: 3.756

4. Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates.

Authors: Christian C Yost; Mark J Cody; Estelle S Harris; Nathan L Thornton; Alison M McInturff; Mark L Martinez; Nancy B Chandler; Christopher K Rodesch; Kurt H Albertine; Cathy A Petti; Andrew S Weyrich; Guy A Zimmerman
Journal: Blood Date: 2009-02-12 Impact factor: 22.113

5. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.

Authors: M E Belderbos; G M van Bleek; O Levy; M O Blanken; M L Houben; L Schuijff; J L L Kimpen; L Bont
Journal: Clin Immunol Date: 2009-08-03 Impact factor: 3.969

Neonatal neutrophils: the good, the bad, and the ugly.

1. Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants.

2. Murine neonates are highly resistant to Yersinia enterocolitica following orogastric exposure.

3. Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4.

4. Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates.

5. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.

Review 6. Group B streptococcus and early-onset sepsis in the era of maternal prophylaxis.

7. Effect of pregnancy induced hypertension on mothers and their babies.

8. Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils.

9. RTX toxin plays a key role in Kingella kingae virulence in an infant rat model.

Review 10. Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes.