| Literature DB >> 15183626 |
Brunangelo Falini1, Enrico Tiacci, Arcangelo Liso, Katia Basso, Elena Sabattini, Roberta Pacini, Robin Foa, Alessandro Pulsoni, Riccardo Dalla Favera, Stefano Pileri.
Abstract
A marker capable of distinguishing with certainty between hairy cell leukaemia and other B-cell malignant disease would be of great diagnostic value. Through gene expression profiling, annexin A1 (ANXA1) has been identified as a gene that is upregulated in hairy cell leukaemia. We did immunostaining of 500 B-cell tumours with a specific anti-ANXA1 monoclonal antibody and showed that ANXA1 protein expression is specific to hairy cell leukaemia. Immunocytochemical detection of ANXA1 represents a simple, inexpensive, highly sensitive and specific (100%) assay for diagnosis of hairy cell leukaemia. This assay will be especially useful in distinguishing hairy cell leukaemia from splenic lymphoma with villous lymphocytes and variant hairy cell leukaemia, both of which usually respond poorly to treatments that are effective in hairy cell leukaemia.Entities:
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Year: 2004 PMID： 15183626 DOI： 10.1016/S0140-6736(04)16356-3
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321