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Literature DB >> 15182702

An overview of the KIN1/PAR-1/MARK kinase family.

Abstract

Members of the KIN1/PAR-1/MARK kinase family are conserved from yeast to humans and share a similar primary structural organization. Several kinases of this family appear to be at the crossroads of various biological functions including cell polarity, cell cycle control, intracellular signalisation, microtubules stability and protein stability. Here we present an overview of known roles of KIN1/PAR-1/MARK kinases including pEg3 a newly identified member which is regulated during the cell cycle and is a potential regulator of the cell cycle progression. Some common modes of action can be deciphered for this protein kinase family.

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Year: 2004 PMID： 15182702 DOI： 10.1016/j.biolcel.2003.10.009

Source DB: PubMed Journal: Biol Cell ISSN： 0248-4900 Impact factor: 4.458

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Cited

42 in total

1. Solution structure of the kinase-associated domain 1 of mouse microtubule-associated protein/microtubule affinity-regulating kinase 3.

Authors: Naoya Tochio; Seizo Koshiba; Naohiro Kobayashi; Makoto Inoue; Takashi Yabuki; Masaaki Aoki; Eiko Seki; Takayoshi Matsuda; Yasuko Tomo; Yoko Motoda; Atsuo Kobayashi; Akiko Tanaka; Yoshihide Hayashizaki; Takaho Terada; Mikako Shirouzu; Takanori Kigawa; Shigeyuki Yokoyama
Journal: Protein Sci Date: 2006-11 Impact factor: 6.725

An overview of the KIN1/PAR-1/MARK kinase family.

1. Solution structure of the kinase-associated domain 1 of mouse microtubule-associated protein/microtubule affinity-regulating kinase 3.

2. Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast.

3. Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis.

Review 4. The PAR proteins: fundamental players in animal cell polarization.

Review 5. Polarity regulation in migrating neurons in the cortex.

Review 6. Tau as a therapeutic target for Alzheimer's disease.

7. MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells.

8. A novel role for protein kinase Kin2 in regulating HAC1 mRNA translocation, splicing, and translation.

Review 9. MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis.

10. The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3.