| Literature DB >> 15182694 |
Abstract
Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome. Copyright 2004 Elsevier Ltd.Entities:
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Year: 2004 PMID: 15182694 DOI: 10.1016/j.cub.2004.05.039
Source DB: PubMed Journal: Curr Biol ISSN: 0960-9822 Impact factor: 10.834