Literature DB >> 15182229

PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex.

Jennifer J Carlisle Michel1, Kimberly L Dodge, Wei Wong, Nicole C Mayer, Lorene K Langeberg, John D Scott.   

Abstract

mAKAP (muscle-selective A-kinase-anchoring protein) co-ordinates a cAMP-sensitive negative-feedback loop comprising PKA (cAMP-dependent protein kinase) and the cAMP-selective PDE4D3 (phosphodiesterase 4D3). In vitro and cellular experiments demonstrate that PKA-phosphorylation of PDE4D3 on Ser-13 increases the affinity of PDE4D3 for mAKAP. Our data suggest that activation of mAKAP-anchored PKA enhances the recruitment of PDE4D3, allowing for quicker signal termination.

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Year:  2004        PMID： 15182229      PMCID： PMC1133866          DOI： 10.1042/BJ20040846

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

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Authors:  M Colledge; J D Scott
Journal:  Trends Cell Biol       Date:  1999-06       Impact factor: 20.808

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3.  The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform.

Authors:  S J Yarwood; M R Steele; G Scotland; M D Houslay; G B Bolger
Journal:  J Biol Chem       Date:  1999-05-21       Impact factor: 5.157

4.  Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.

Authors:  C Sette; M Conti
Journal:  J Biol Chem       Date:  1996-07-12       Impact factor: 5.157

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Authors:  R Alvarez; C Sette; D Yang; R M Eglen; R Wilhelm; E R Shelton; M Conti
Journal:  Mol Pharmacol       Date:  1995-10       Impact factor: 4.436

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9.  cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.

Authors:  R Hoffmann; I R Wilkinson; J F McCallum; P Engels; M D Houslay
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8.  Signaling at crossroads: the dialogue between PDEs and PKA is spoken in multiple languages.

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