Literature DB >> 15182224

Alpha-synuclein and the pathogenesis of Parkinson's disease.

Francis L Martin1, Sally J M Williamson, Katerina E Paleologou, David Allsop, Omar M A El-Agnaf.   

Abstract

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of alpha-synuclein (alpha-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

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Year:  2004        PMID： 15182224     DOI： 10.2174/0929866043407138

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  9 in total

1.  RNA interference mediated silencing of alpha-synuclein in MN9D cells and its effects on cell viability.

Authors:  Dong-Mei Liu; Ling Jin; Hao Wang; Huan-Ying Zhao; Chun-Li Zhao; Hui Yang
Journal:  Neurosci Bull       Date:  2008-04       Impact factor: 5.203

Review 2.  Rifampicin and Parkinson's disease.

Authors:  Wei Bi; Lihong Zhu; Xiuna Jing; Yanran Liang; Enxiang Tao
Journal:  Neurol Sci       Date:  2012-07-21       Impact factor: 3.307

Review 3.  The ongoing pursuit of neuroprotective therapies in Parkinson disease.

Authors:  Dilan Athauda; Thomas Foltynie
Journal:  Nat Rev Neurol       Date:  2014-12-02       Impact factor: 42.937

Review 4.  A synopsis on the role of tyrosine hydroxylase in Parkinson's disease.

Authors:  Shams Tabrez; Nasimudeen R Jabir; Shazi Shakil; Nigel H Greig; Qamre Alam; Adel M Abuzenadah; Ghazi A Damanhouri; Mohammad A Kamal
Journal:  CNS Neurol Disord Drug Targets       Date:  2012-06-01       Impact factor: 4.388

5.  α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.

Authors:  Brian Spencer; Changyoun Kim; Tania Gonzalez; Alejandro Bisquertt; Christina Patrick; Edward Rockenstein; Anthony Adame; Seung-Jae Lee; Paula Desplats; Eliezer Masliah
Journal:  Hum Mol Genet       Date:  2016-01-05       Impact factor: 6.150

6.  Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients.

Authors:  Federica Piancone; Marina Saresella; Francesca La Rosa; Ivana Marventano; Mario Meloni; Jorge Navarro; Mario Clerici
Journal:  Front Neurosci       Date:  2021-03-25       Impact factor: 4.677

7.  Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells.

Authors:  Dongmei Liu; Ling Jin; Hao Wang; Huanying Zhao; Chunli Zhao; Chunli Duan; Lingling Lu; Bo Wu; Shun Yu; Piu Chan; Yaohua Li; Hui Yang
Journal:  Neurochem Res       Date:  2008-03-21       Impact factor: 3.996

8.  Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant.

Authors:  Claire Hoenen; Audrey Gustin; Cindy Birck; Mélanie Kirchmeyer; Nicolas Beaume; Paul Felten; Luc Grandbarbe; Paul Heuschling; Tony Heurtaux
Journal:  PLoS One       Date:  2016-09-13       Impact factor: 3.240

9.  Plasma Levels of α-Synuclein, Aβ-40 and T-tau as Biomarkers to Predict Cognitive Impairment in Parkinson's Disease.

Authors:  Nai-Ching Chen; Hsiu-Ling Chen; Shau-Hsuan Li; Yen-Hsiang Chang; Meng-Hsiang Chen; Nai-Wen Tsai; Chiun-Chieh Yu; Shieh-Yueh Yang; Cheng-Hsien Lu; Wei-Che Lin
Journal:  Front Aging Neurosci       Date:  2020-04-28       Impact factor: 5.750
  9 in total

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