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Literature DB >> 15180508

Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins.

Abstract

The toxicity to cells and animals of type 1 and toxic and non-toxic type 2 Ribosome-Inactivating Proteins (RIP) is discussed in correlation with their catalytic activity, resulting in ribosome inactivation and apoptosis. The symptoms and histopathological lesions induced by RIP to animals and humans is also reviewed.

Entities: Disease Species

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Year: 2004 PMID： 15180508 DOI： 10.2174/1389557043403819

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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Cited

18 in total

1. Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells.

Authors: C Horrix; Z Raviv; E Flescher; C Voss; M R Berger
Journal: Cell Mol Life Sci Date: 2010-09-16 Impact factor: 9.261

2. Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites.

Authors: Martin J Spiering; Lori A Urban; Donald L Nuss; Vivek Gopalan; Arlin Stoltzfus; Edward Eisenstein
Journal: Plant Cell Rep Date: 2010-12-28 Impact factor: 4.570

3. Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Authors: Xiao-Ping Li; Peter C Kahn; Jennifer Nielsen Kahn; Przemyslaw Grela; Nilgun E Tumer
Journal: J Biol Chem Date: 2013-09-03 Impact factor: 5.157

Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins.

1. Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells.

2. Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites.

3. Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

4. In silico analysis of molecular mechanisms of legume lectin-induced apoptosis in cancer cells.

5. Mechanism of the specific neuronal toxicity of a type I ribosome-inactivating protein, trichosanthin.

6. Stress-induced curcin-L promoter in leaves of Jatropha curcas L. and characterization in transgenic tobacco.

7. Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy.

Review 8. Immunotoxins and anticancer drug conjugate assemblies: the role of the linkage between components.

9. Llama-derived single domain antibodies specific for Abrus agglutinin.

10. Effect of pH on anti-rotavirus activity by comestible juices and proanthocyanidins in a cell-free assay system.