Literature DB >> 15180507

Ribosome-inactivating proteins: entry into mammalian cells and intracellular routing.

Lynne M Roberts1, J Michael Lord.   

Abstract

To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.

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Year:  2004        PMID： 15180507     DOI： 10.2174/1389557043403846

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  9 in total

1.  Expression of functional hexahistidine-tagged ricin B in tobacco.

Authors:  Deborah G Reed; Luis H Nopo-Olazabal; Vanessa Funk; Bonnie J Woffenden; Michael J Reidy; Maureen C Dolan; Carole L Cramer; Fabricio Medina-Bolivar
Journal:  Plant Cell Rep       Date:  2004-12-15       Impact factor: 4.570

2.  Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties.

Authors:  Christopher M Pirie; Benjamin J Hackel; Michael G Rosenblum; K Dane Wittrup
Journal:  J Biol Chem       Date:  2010-12-07       Impact factor: 5.157

3.  [Paraoxonase 1 gene polymorphism 192Q/R in old men and long-livers from Tatars ethnic group].

Authors:  V V Pauk; I A Tuktarova; T R Nasibullin; L P Zueva; A Kh Adel'guzhina; E K Khusnutdinova; O E Mustafina
Journal:  Mol Biol (Mosk)       Date:  2007 Jul-Aug

4.  Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells.

Authors:  Wei Wang; Christine Hale; Dave Goulding; Stuart M Haslam; Bérangère Tissot; Christopher Lindsay; Stephen Michell; Rick Titball; Jun Yu; Ana Luisa Toribio; Raffaella Rossi; Anne Dell; Allan Bradley; Gordon Dougan
Journal:  PLoS One       Date:  2011-08-23       Impact factor: 3.240

Review 5.  Toxin-based therapeutic approaches.

Authors:  Assaf Shapira; Itai Benhar
Journal:  Toxins (Basel)       Date:  2010-10-28       Impact factor: 4.546

Review 6.  Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications.

Authors:  Moo-Seung Lee; Sunwoo Koo; Dae Gwin Jeong; Vernon L Tesh
Journal:  Toxins (Basel)       Date:  2016-03-17       Impact factor: 4.546

7.  Ricin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 {degrees}C.

Authors:  Peter U Mayerhofer; Jonathan P Cook; Judit Wahlman; Teresa T J Pinheiro; Katherine A H Moore; J Michael Lord; Arthur E Johnson; Lynne M Roberts
Journal:  J Biol Chem       Date:  2009-02-11       Impact factor: 5.157

8.  Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism.

Authors:  Kerry L Chamberlain; Richard S Marshall; Nicholas A Jolliffe; Lorenzo Frigerio; Aldo Ceriotti; J Michael Lord; Lynne M Roberts
Journal:  J Biol Chem       Date:  2008-10-02       Impact factor: 5.157

Review 9.  The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations.

Authors:  Aleksander Rust; Lynda J Partridge; Bazbek Davletov; Guillaume M Hautbergue
Journal:  Toxins (Basel)       Date:  2017-10-27       Impact factor: 4.546
  9 in total

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