Literature DB >> 15180504

The structure of ribosome inactivating proteins.

Jon D Robertus1, Arthur F Monzingo.   

Abstract

Ribosome Inactivating Proteins, RIPs, depurinate an invariant adenine from the 28S rRNA of eukaryotic ribosomes; they have evolved to near enzymatic perfection for this task. The N-glycosidase fold is conserved in plant and bacterial enzymes. RIPs can form complexes with cell surface recognition proteins that dramatically increase the cytotoxicity of the molecule.

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Year:  2004        PMID： 15180504     DOI： 10.2174/1389557043403837

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  19 in total

1.  Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.

Authors:  Amanda E Jetzt; Xiao-Ping Li; Nilgun E Tumer; Wendie S Cohick
Journal:  Toxicol Appl Pharmacol       Date:  2016-09-15       Impact factor: 4.219

2.  Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen.

Authors:  Paul G Wahome; Yan Bai; Lori M Neal; Jon D Robertus; Nicholas J Mantis
Journal:  Toxicon       Date:  2010-03-27       Impact factor: 3.033

3.  Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.

Authors:  Meng-Chiao Ho; Matthew B Sturm; Steven C Almo; Vern L Schramm
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-17       Impact factor: 11.205

4.  Biological activities of the antiviral protein BE27 from sugar beet (Beta vulgaris L.).

Authors:  Rosario Iglesias; Lucía Citores; Antimo Di Maro; José M Ferreras
Journal:  Planta       Date:  2014-10-19       Impact factor: 4.116

5.  Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes.

Authors:  Xiao-Ping Li; Rajesh K Harijan; Jennifer N Kahn; Vern L Schramm; Nilgun E Tumer
Journal:  ACS Infect Dis       Date:  2020-06-08       Impact factor: 5.084

6.  Identification of new classes of ricin toxin inhibitors by virtual screening.

Authors:  Yan Bai; Beth Watt; Paul G Wahome; Nicholas J Mantis; Jon D Robertus
Journal:  Toxicon       Date:  2010-05-20       Impact factor: 3.033

7.  A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.

Authors:  Xiao-Ping Li; Jia-Chi Chiou; Miguel Remacha; Juan P G Ballesta; Nilgun E Tumer
Journal:  Biochemistry       Date:  2009-05-12       Impact factor: 3.162

Review 8.  Structure-based design of ricin inhibitors.

Authors:  Karl Jasheway; Jeffrey Pruet; Eric V Anslyn; Jon D Robertus
Journal:  Toxins (Basel)       Date:  2011-10-13       Impact factor: 4.546

9.  Llama-derived single domain antibodies specific for Abrus agglutinin.

Authors:  Ellen R Goldman; George P Anderson; Dan Zabetakis; Scott Walper; Jinny L Liu; Rachael Bernstein; Alena Calm; James P Carney; Thomas W O'Brien; Jennifer L Walker; Eric A E Garber
Journal:  Toxins (Basel)       Date:  2011-11-11       Impact factor: 4.546

10.  Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities.

Authors:  Yuen-Ting Wong; Yiu-Ming Ng; Amanda Nga-Sze Mak; Kong-Hung Sze; Kam-Bo Wong; Pang-Chui Shaw
Journal:  PLoS One       Date:  2012-12-12       Impact factor: 3.240
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