Literature DB >> 1518039

Monoclonal antibodies to a 16-kDa antigen of Serpulina (Treponema) hyodysenteriae.

W Thomas1, R Sellwood.   

Abstract

Monoclonal antibodies (MAbs) were produced to an outer-envelope preparation from Serpulina (Treponema) hyodysenteriae, the aetiological agent of swine dysentery. Three MAbs (isotype IgG1) were obtained. All three recognised a 16-kDa antigen that was common to most strains of S. hyodysenteriae of different serotypes but was absent from nonpathogenic, porcine intestinal spirochaetes. Immunofluorescence and immunogold labelling studies showed that the 16-kDa antigen was exposed on the surface of intact spirochaetes. The MAbs agglutinated freshly grown cultures of spirochaetes and inhibited growth of S. hyodysenteriae strains in vitro.

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Year:  1992        PMID： 1518039     DOI： 10.1099/00222615-37-3-214

Source DB:  PubMed          Journal:  J Med Microbiol        ISSN： 0022-2615            Impact factor:   2.472


  7 in total

1.  A 16-kilodalton lipoprotein of the outer membrane of Serpulina (Treponema) hyodysenteriae.

Authors:  W Thomas; R Sellwood; R J Lysons
Journal:  Infect Immun       Date:  1992-08       Impact factor: 3.441

2.  Purified outer membranes of Serpulina hyodysenteriae contain cholesterol.

Authors:  H Plaza; T R Whelchel; S F Garczynski; E W Howerth; F C Gherardini
Journal:  J Bacteriol       Date:  1997-09       Impact factor: 3.490

3.  Molecular cloning, expression, and DNA sequence analysis of the gene that encodes the 16-kilodalton outer membrane lipoprotein of Serpulina hyodysenteriae.

Authors:  W Thomas; R Sellwood
Journal:  Infect Immun       Date:  1993-03       Impact factor: 3.441

4.  Rapid detection of Serpulina hyodysenteriae in diagnostic specimens by PCR.

Authors:  R O Elder; G E Duhamel; R W Schafer; M R Mathiesen; M Ramanathan
Journal:  J Clin Microbiol       Date:  1994-06       Impact factor: 5.948

5.  Production and characterization of monoclonal antibodies against Serpulina hyodysenteriae and S. innocens and their use in serotyping.

Authors:  M Achacha; K R Mittal
Journal:  J Clin Microbiol       Date:  1995-09       Impact factor: 5.948

6.  Adherence of Brachyspira hyodysenteriae to porcine intestinal epithelial cells is inhibited by antibodies against outer membrane proteins.

Authors:  Maike Gömmel; Stefanie Barth; Carsten Heydel; Georg Baljer; Werner Herbst
Journal:  Curr Microbiol       Date:  2012-11-29       Impact factor: 2.188

7.  Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease.

Authors:  R R Montgomery; S E Malawista; K J Feen; L K Bockenstedt
Journal:  J Exp Med       Date:  1996-01-01       Impact factor: 14.307
  7 in total

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