Literature DB >> 15177474

Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation.

Sung-Yu Hong1, Kwang-Hoe Chung, Hea-Jung You, Ik Hwa Choi, Mi Jin Chae, Ja-Young Han, Ok-Jai Jung, Soo-Jung Kang, Chung-Kyu Ryu.   

Abstract

A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.

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Year:  2004        PMID： 15177474     DOI： 10.1016/j.bmcl.2004.04.051

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  A Theoretical and Experimental Study on the Potential Luminescent and Biological Activities of Diaminodicyanoquinodimethane Derivatives.

Authors:  Edison Rafael Jiménez; Manuel Caetano; Nelson Santiago; F Javier Torres; Thibault Terencio; Hortensia Rodríguez
Journal:  Int J Mol Sci       Date:  2021-01-05       Impact factor: 5.923

2.  Highly Active Small Aminated Quinolinequinones against Drug-Resistant Staphylococcus aureus and Candida albicans.

Authors:  Hatice Yıldırım; Nilüfer Bayrak; Mahmut Yıldız; Fatıma Nur Yılmaz; Emel Mataracı-Kara; Deepak Shilkar; Venkatesan Jayaprakash; Amaç Fatih TuYuN
Journal:  Molecules       Date:  2022-05-03       Impact factor: 4.927

3.  Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies.

Authors:  Alejandra Vázquez-Raygoza; Lucia Cano-González; Israel Velázquez-Martínez; Pedro Josué Trejo-Soto; Rafael Castillo; Alicia Hernández-Campos; Francisco Hernández-Luis; Jesús Oria-Hernández; Adriana Castillo-Villanueva; Claudia Avitia-Domínguez; Erick Sierra-Campos; Mónica Valdez-Solana; Alfredo Téllez-Valencia
Journal:  Molecules       Date:  2017-11-24       Impact factor: 4.411

4.  Synthesis and Structure-Activity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents.

Authors:  Jinsu Bae; Yeo-Ok Kim; Xuehao Han; Myung-Ha Yoon; Woong-Mo Kim; Yong-Chul Kim
Journal:  Molecules       Date:  2022-02-16       Impact factor: 4.411
  4 in total

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