| Literature DB >> 15177467 |
Hallur Gurulingappa1, Phillip Buckhalts, Kenneth W Kinzler, Bert Vogelstein, Saeed R Khan.
Abstract
Renal dipeptidase (RDP) is an enzyme overexpressed in benign and malignant colorectal tumors. In an effort to identify potent inhibitors of this enzyme, a series of aminophosphinic acid derivatives were synthesized. Compounds 3a and 3c in which the phenyl ring was para substituted with F and Br and olefin with Z geometry, showed better inhibitory activity against RDP enzyme (IC50 = 5-6 nM).Entities:
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Year: 2004 PMID： 15177467 DOI： 10.1016/j.bmcl.2004.04.057
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823