| Literature DB >> 15177464 |
Kenneth L Smith1, Vicky C H Lai, Brett J Prigaro, Yili Ding, Esmir Gunic, Jean-Luc Girardet, Weidong Zhong, Zhi Hong, Stanley Lang, Haoyun An.
Abstract
Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.Entities:
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Year: 2004 PMID： 15177464 DOI： 10.1016/j.bmcl.2004.04.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823