Literature DB >> 15177461

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.

Jeffrey J Hale1, George Doherty, Leslie Toth, Sander G Mills, Richard Hajdu, Carol Ann Keohane, Mark Rosenbach, James Milligan, Gan-Ju Shei, Gary Chrebet, James Bergstrom, Deborah Card, Michael Forrest, Shu-Yu Sun, Sarah West, Huijuan Xie, Naomi Nomura, Hugh Rosen, Suzanne Mandala.   

Abstract

Structurally modified 3-(N-benzylamino)propylphosphonic acid S1P receptor agonists that maintain affinity for S1P1, and have decreased affinity for S1P3 are efficacious, but exhibit decreased acute cardiovascular toxicity in rodents than do nonselective agonists.

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Year:  2004        PMID： 15177461     DOI： 10.1016/j.bmcl.2004.04.070

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720.

Authors:  Sara M Camp; Eddie T Chiang; Chaode Sun; Peter V Usatyuk; Robert Bittman; Viswanathan Natarajan; Joe G N Garcia; Steven M Dudek
Journal:  Chem Phys Lipids       Date:  2015-08-10       Impact factor: 3.329

Review 2.  Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.

Authors:  Edward J Goetzl; Hugh Rosen
Journal:  J Clin Invest       Date:  2004-12       Impact factor: 14.808

3.  Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.

Authors:  S M Dudek; S M Camp; E T Chiang; P A Singleton; P V Usatyuk; Y Zhao; V Natarajan; J G N Garcia
Journal:  Cell Signal       Date:  2007-04-06       Impact factor: 4.315

4.  Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.

Authors:  Emmanuel H Demont; Benjamin I Andrews; Rino A Bit; Colin A Campbell; Jason W B Cooke; Nigel Deeks; Sapna Desai; Simon J Dowell; Pam Gaskin; James R J Gray; Andrea Haynes; Duncan S Holmes; Umesh Kumar; Mary A Morse; Greg J Osborne; Terry Panchal; Bela Patel; Alcide Perboni; Simon Taylor; Robert Watson; Jason Witherington; Robert Willis
Journal:  ACS Med Chem Lett       Date:  2011-03-24       Impact factor: 4.345

5.  FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury.

Authors:  Lichun Wang; Saad Sammani; Liliana Moreno-Vinasco; Eleftheria Letsiou; Ting Wang; Sara M Camp; Robert Bittman; Joe G N Garcia; Steven M Dudek
Journal:  Crit Care Med       Date:  2014-03       Impact factor: 7.598

6.  Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs.

Authors:  Biji Mathew; Jeffrey R Jacobson; Evgeny Berdyshev; Yong Huang; Xiaoguang Sun; Yutong Zhao; Lynnette M Gerhold; Jessica Siegler; Carrie Evenoski; Ting Wang; Tong Zhou; Rafe Zaidi; Liliana Moreno-Vinasco; Robert Bittman; Chin Tu Chen; Patrick J LaRiviere; Saad Sammani; Yves A Lussier; Steven M Dudek; Viswanathan Natarajan; Ralph R Weichselbaum; Joe G N Garcia
Journal:  FASEB J       Date:  2011-06-28       Impact factor: 5.191

7.  Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro.

Authors:  S M Camp; R Bittman; E T Chiang; L Moreno-Vinasco; T Mirzapoiazova; S Sammani; X Lu; C Sun; M Harbeck; M Roe; V Natarajan; J G N Garcia; S M Dudek
Journal:  J Pharmacol Exp Ther       Date:  2009-07-10       Impact factor: 4.030

Review 8.  Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions.

Authors:  Abby L Parrill; Gabor Tigyi
Journal:  Biochim Biophys Acta       Date:  2012-09-12

9.  Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.

Authors:  Mor M Naor; Michelle D Walker; James R Van Brocklyn; Gabor Tigyi; Abby L Parrill
Journal:  J Mol Graph Model       Date:  2007-03-14       Impact factor: 2.518

10.  FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology.

Authors:  Kunitomo Adachi; Kenji Chiba
Journal:  Perspect Medicin Chem       Date:  2007-09-06
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