| Literature DB >> 15177457 |
F Kuo1, T A Gillespie, P Kulanthaivel, R J Lantz, T W Ma, D L Nelson, P G Threlkeld, W J Wheeler, P Yi, M Zmijewski.
Abstract
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.Entities:
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Year: 2004 PMID： 15177457 DOI： 10.1016/j.bmcl.2004.04.066
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823