| Literature DB >> 15177456 |
Ariamala Gopalsamy1, Scott L Kincaid, John W Ellingboe, Thomas M Groeling, Thomas M Antrilli, Girija Krishnamurthy, Ann Aulabaugh, Gregory S Friedrichs, David L Crandall.
Abstract
A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening. Optimization of substituents by parallel synthesis and the iterative design toward understanding structure-activity relationship to improve potency are described.Entities:
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Year: 2004 PMID： 15177456 DOI： 10.1016/j.bmcl.2004.04.058
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823