Literature DB >> 15177441

Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV.

Jonathan D Bloom1, Russell G Dushin, Kevin J Curran, Fran Donahue, Emily B Norton, Eugene Terefenko, Thomas R Jones, Adma A Ross, Boris Feld, Stanley A Lang, Martin J DiGrandi.   

Abstract

A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM.

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Year:  2004        PMID: 15177441     DOI: 10.1016/j.bmcl.2004.04.093

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Current and potential treatments for ubiquitous but neglected herpesvirus infections.

Authors:  Jonathan E Gable; Timothy M Acker; Charles S Craik
Journal:  Chem Rev       Date:  2014-10-02       Impact factor: 60.622

2.  Cytomegalovirus UL131-128 products promote gB conformational transition and gB-gH interaction during entry into endothelial cells.

Authors:  Marco Patrone; Massimiliano Secchi; Eleonora Bonaparte; Gabriele Milanesi; Andrea Gallina
Journal:  J Virol       Date:  2007-08-08       Impact factor: 5.103

3.  Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion.

Authors:  Yuhang Liu; Kyle P Heim; Ye Che; Xiaoyuan Chi; Xiayang Qiu; Seungil Han; Philip R Dormitzer; Xinzhen Yang
Journal:  Sci Adv       Date:  2021-03-05       Impact factor: 14.136

4.  Applications of Cryo-EM in small molecule and biologics drug design.

Authors:  Joshua A Lees; Joao M Dias; Seungil Han
Journal:  Biochem Soc Trans       Date:  2021-12-17       Impact factor: 5.407

5.  Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies.

Authors:  Anna Bielenica; Giuseppina Sanna; Silvia Madeddu; Gabriele Giliberti; Joanna Stefańska; Anna E Kozioł; Oleksandra Savchenko; Paulina Strzyga-Łach; Alicja Chrzanowska; Grażyna Kubiak-Tomaszewska; Marta Struga
Journal:  Molecules       Date:  2018-09-21       Impact factor: 4.411

  5 in total

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