| Literature DB >> 15177439 |
Lawrence A Reiter1, Ralph P Robinson, Kim F McClure, Christopher S Jones, Matthew R Reese, Peter G Mitchell, Ivan G Otterness, Marcia L Bliven, Jennifer Liras, Santo R Cortina, Kathleen M Donahue, James D Eskra, Richard J Griffiths, Mary E Lame, Arturo Lopez-Anaya, Gary J Martinelli, Shunda M McGahee, Sue A Yocum, Lori L Lopresti-Morrow, Lisa M Tobiassen, Marcie L Vaughn-Bowser.
Abstract
The SAR of a series of sterically hindered sulfonamide hydroxamic acids with relatively large P1' groups is described. The compounds typically spare MMP-1 while being potent inhibitors of MMP-13. The metabolically more stable compounds in the series contain either a monocyclic or bicyclic pyran ring adjacent to the hydroxamate group. Despite the sparing of MMP-1, pre-clinical and clinical studies revealed that fibrosis in rats and MSS in humans is still produced.Entities:
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Year: 2004 PMID： 15177439 DOI： 10.1016/j.bmcl.2004.04.083
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823