| Literature DB >> 15177194 |
Kristine M Rose1, Mariana Marin, Susan L Kozak, David Kabat.
Abstract
The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for its investigation. These limitations have been overcome and Vif function has been rapidly elucidated, with implications for the development of drugs to block its activity. These studies have revealed a novel component of the innate immune system, APOBEC3G, that lethally hypermutates retroviruses, including HIV-1. For HIV-1, the competition between the virus and APOBEC3G is tipped in favor of the invader by Vif, which binds to APOBEC3G and triggers its polyubiquitination and rapid degradation, thereby preventing its entry into progeny virions.Entities:
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Year: 2004 PMID： 15177194 DOI： 10.1016/j.molmed.2004.04.008
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951