| Literature DB >> 15177020 |
Abstract
The Arf tumor suppressor is a key component of the p53 tumor surveillance pathway, and its expression is activated by abnormal proliferation signals. In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf.Entities:
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Year: 2004 PMID： 15177020 DOI： 10.1016/j.devcel.2004.05.012
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270