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Literature DB >> 15176867

Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa.

Alessandro Usseglio Viretta¹, Martin Fussenegger.

Abstract

The biochemical network underlying quorum sensing in human-pathogenic Pseudomonas aeruginosa is one of the best characterized. Mathematical modeling is required to untangle the complexity of its architecture and dynamics. We present a qualitative model of the P. aeruginosa quorum-sensing network including interactions between the las and rhl modules, the signaling molecule PQS and the regulatory proteins Mvfr and VfR. Simulations exemplify the model to reproduce natural network behavior and suggest quorum-sensing responses to pharmacological interference.

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Year: 2004 PMID： 15176867 DOI： 10.1021/bp034323l

Source DB: PubMed Journal: Biotechnol Prog ISSN： 1520-6033

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Cited

12 in total

1. Piecewise-linear models of genetic regulatory networks: equilibria and their stability.

Authors: Richard Casey; Hidde de Jong; Jean-Luc Gouzé
Journal: J Math Biol Date: 2005-09-29 Impact factor: 2.259

2. Hierarchical analysis of piecewise affine models of gene regulatory networks.

Authors: Laurent Tournier; Jean-Luc Gouzé
Journal: Theory Biosci Date: 2008-04-25 Impact factor: 1.919

3. Homologous Quorum Sensing Regulatory Circuit: A Dual-Input Genetic Controller for Modulating Quorum Sensing-Mediated Protein Expression in E. coli.

Authors: Pricila Hauk; Kristina Stephens; Chelsea Virgile; Eric VanArsdale; Alex Eli Pottash; John S Schardt; Steven M Jay; Herman O Sintim; William E Bentley
Journal: ACS Synth Biol Date: 2020-09-15 Impact factor: 5.110

10. Characterization and complete sequence of lactonase enzyme from Bacillus weihenstephanensis isolate P65 with potential activity against acyl homoserine lactone signal molecules.

Authors: Masarra Mohammed Sakr; Khaled Mohamed Anwar Aboshanab; Mohammad Mabrouk Aboulwafa; Nadia Abdel-Haleem Hassouna
Journal: Biomed Res Int Date: 2013-07-09 Impact factor: 3.411

Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa.

1. Piecewise-linear models of genetic regulatory networks: equilibria and their stability.

2. Hierarchical analysis of piecewise affine models of gene regulatory networks.

3. Homologous Quorum Sensing Regulatory Circuit: A Dual-Input Genetic Controller for Modulating Quorum Sensing-Mediated Protein Expression in E. coli.

4. Information transmission in microbial and fungal communication: from classical to quantum.

5. A synthetic time-delay circuit in mammalian cells and mice.

6. A self-organized model for cell-differentiation based on variations of molecular decay rates.

7. Transition to quorum sensing in an Agrobacterium population: A stochastic model.

Review 8. An evolving perspective on the Pseudomonas aeruginosa orphan quorum sensing regulator QscR.

9. An overview of existing modeling tools making use of model checking in the analysis of biochemical networks.

10. Characterization and complete sequence of lactonase enzyme from Bacillus weihenstephanensis isolate P65 with potential activity against acyl homoserine lactone signal molecules.