Literature DB >> 15176809

SimplePHOX, a readily available chiral ligand system for iridium-catalyzed asymmetric hydrogenation.

Sebastian P Smidt1, Frederik Menges, Andreas Pfaltz.   

Abstract

[reaction: see text] New Ir-SimplePHOX complexes Ir-6-Ir-9 catalyze the quantitative, highly enantioselective hydrogenation of a range of unfunctionalized and functionalized olefins. Synthesis, catalytic results, and X-ray crystal structures are presented here.

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Year:  2004        PMID： 15176809     DOI： 10.1021/ol049235w

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Enantioselective decarboxylative alkylation reactions: catalyst development, substrate scope, and mechanistic studies.

Authors:  Douglas C Behenna; Justin T Mohr; Nathaniel H Sherden; Smaranda C Marinescu; Andrew M Harned; Kousuke Tani; Masaki Seto; Sandy Ma; Zoltán Novák; Michael R Krout; Ryan M McFadden; Jennifer L Roizen; John A Enquist; David E White; Samantha R Levine; Krastina V Petrova; Akihiko Iwashita; Scott C Virgil; Brian M Stoltz
Journal:  Chemistry       Date:  2011-11-14       Impact factor: 5.236

2.  Double-asymmetric hydrogenation strategy for the reduction of 1,1-diaryl olefins applied to an improved synthesis of CuIPhEt, a C2-symmetric N-heterocyclic carbenoid.

Authors:  Elizabeth Spahn; Abigail Albright; Michael Shevlin; Larissa Pauli; Andreas Pfaltz; Robert E Gawley
Journal:  J Org Chem       Date:  2013-02-19       Impact factor: 4.354

3.  Comparison Of Asymmetric Hydrogenations Of Unsaturated- Carboxylic Acids And -Esters.

Authors:  Sakunchai Khumsubdee; Kevin Burgess
Journal:  ACS Catal       Date:  2013-02-01       Impact factor: 13.084

4.  NeoPHOX - a structurally tunable ligand system for asymmetric catalysis.

Authors:  Jaroslav Padevět; Marcus G Schrems; Robin Scheil; Andreas Pfaltz
Journal:  Beilstein J Org Chem       Date:  2016-06-13       Impact factor: 2.883

5.  Iridium-Catalyzed Asymmetric Hydrogenation of 2,3-Diarylallyl Amines with a Threonine-Derived P-Stereogenic Ligand for the Synthesis of Tetrahydroquinolines and Tetrahydroisoquinolines.

Authors:  Pep Rojo; Medea Molinari; Albert Cabré; Clara García-Mateos; Antoni Riera; Xavier Verdaguer
Journal:  Angew Chem Int Ed Engl       Date:  2022-05-31       Impact factor: 16.823
  5 in total

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