Literature DB >> 15176791

Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family.

Robert H Cichewicz1, Frederick A Valeriote, Phillip Crews.   

Abstract

[structure: see text] Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.

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Year:  2004        PMID： 15176791     DOI： 10.1021/ol049503q

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  39 in total

Review 1.  Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants.

Authors:  Ocky K Radjasa; Yvette M Vaske; Gabriel Navarro; Hélène C Vervoort; Karen Tenney; Roger G Linington; Phillip Crews
Journal:  Bioorg Med Chem       Date:  2011-07-26       Impact factor: 3.641

2.  Synthesis of Unusually Strained Spiro Ring Systems and Their Exploits in Synthesis.

Authors:  Richard J Duffy; Kay A Morris; Daniel Romo
Journal:  Tetrahedron       Date:  2009-09-01       Impact factor: 2.457

3.  Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products.

Authors:  Xin Jiang; Noelle Williams; Jef K De Brabander
Journal:  Org Lett       Date:  2007-01-18       Impact factor: 6.005

4.  INTEGRATED APPROACHES TO THE CONFIGURATIONAL ASSIGNMENT OF MARINE NATURAL PRODUCTS.

Authors:  Tadeusz F Molinski; Brandon I Morinaka
Journal:  Tetrahedron       Date:  2012-11-18       Impact factor: 2.457

5.  Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses.

Authors:  Annette Kampa; Andrey N Gagunashvili; Tobias A M Gulder; Brandon I Morinaka; Cristina Daolio; Markus Godejohann; Vivian P W Miao; Jörn Piel; Ólafur S Andrésson
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-29       Impact factor: 11.205

6.  Hidden biosynthetic treasures brought to light.

Authors:  Christian Hertweck
Journal:  Nat Chem Biol       Date:  2009-07       Impact factor: 15.040

7.  Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1.

Authors:  Seiya Hirano; Hue Tu Quach; Tsubasa Watanabe; Naoki Kanoh; Yoshiharu Iwabuchi; Takeo Usui; Takao Kataoka
Journal:  J Antibiot (Tokyo)       Date:  2015-01-28       Impact factor: 2.649

8.  Polyketide proofreading by an acyltransferase-like enzyme.

Authors:  Katja Jensen; Holger Niederkrüger; Katrin Zimmermann; Anna L Vagstad; Jana Moldenhauer; Nicole Brendel; Sarah Frank; Petra Pöplau; Christoph Kohlhaas; Craig A Townsend; Marco Oldiges; Christian Hertweck; Jörn Piel
Journal:  Chem Biol       Date:  2012-03-23

9.  Total synthesis of (+)-psymberin (irciniastatin A): catalytic reagent control as the strategic cornerstone.

Authors:  Amos B Smith; Jon A Jurica; Shawn P Walsh
Journal:  Org Lett       Date:  2008-12-18       Impact factor: 6.005

10.  Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting.

Authors:  Katja M Fisch; Cristian Gurgui; Nina Heycke; Sonia A van der Sar; Sally A Anderson; Victoria L Webb; Stefan Taudien; Matthias Platzer; Brent K Rubio; Sarah J Robinson; Phillip Crews; Jörn Piel
Journal:  Nat Chem Biol       Date:  2009-07       Impact factor: 15.040
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