Literature DB >> 15176480

Effects of antidepressant drug imipramine on gene expression in rat prefrontal cortex.

Juha E A Knuuttila1, Petri Törönen, Eero Castrén.   

Abstract

We have investigated gene expression changes produced by acute and chronic daily treatment with a prototypical antidepressant, imipramine, using DNA microarrays. The analysis of similarities in gene expression patterns among functionally related genes revealed four expression profile cluster areas that showed a highly significant overrepresentation of several functional classes. Genes encoding for proteins involved in cAMP metabolism, postsynaptic membrane proteins, and proto-oncogenes were overrepresented in different cluster areas. Furthermore, we found that serine proteases as a group were similarly regulated by chronic antidepressant treatment. Our data suggest that cAMP metabolism, synaptic function, and protein processing by serine proteases may be important targets of antidepressant treatment and potential objects for antidepressant drug development.

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Year:  2004        PMID： 15176480     DOI： 10.1023/b:nere.0000023610.89631.d6

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  60 in total

1.  Global functional profiling of gene expression.

Authors:  Sorin Draghici; Purvesh Khatri; Rui P Martins; G Charles Ostermeier; Stephen A Krawetz
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2.  Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.

Authors:  S J Mowla; H F Farhadi; S Pareek; J K Atwal; S J Morris; N G Seidah; R A Murphy
Journal:  J Biol Chem       Date:  2001-01-10       Impact factor: 5.157

3.  Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.

Authors:  B T Hope; H E Nye; M B Kelz; D W Self; M J Iadarola; Y Nakabeppu; R S Duman; E J Nestler
Journal:  Neuron       Date:  1994-11       Impact factor: 17.173

Review 4.  Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression.

Authors:  Husseini K Manji; Jorge A Quiroz; Jonathan Sporn; Jennifer L Payne; Kirk Denicoff; Neil A Gray; Carlos A Zarate; Dennis S Charney
Journal:  Biol Psychiatry       Date:  2003-04-15       Impact factor: 13.382

5.  Enhancement of hippocampal neurogenesis by lithium.

Authors:  G Chen; G Rajkowska; F Du; N Seraji-Bozorgzad; H K Manji
Journal:  J Neurochem       Date:  2000-10       Impact factor: 5.372

6.  Identifying biological themes within lists of genes with EASE.

Authors:  Douglas A Hosack; Glynn Dennis; Brad T Sherman; H Clifford Lane; Richard A Lempicki
Journal:  Genome Biol       Date:  2003-09-11       Impact factor: 13.583

7.  The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

Authors:  Michael F Egan; Masami Kojima; Joseph H Callicott; Terry E Goldberg; Bhaskar S Kolachana; Alessandro Bertolino; Eugene Zaitsev; Bert Gold; David Goldman; Michael Dean; Bai Lu; Daniel R Weinberger
Journal:  Cell       Date:  2003-01-24       Impact factor: 41.582

8.  Chronic desipramine alters stress-induced behaviors and regional expression of the immediate early gene, c-fos.

Authors:  C H Beck; H C Fibiger
Journal:  Pharmacol Biochem Behav       Date:  1995 Jun-Jul       Impact factor: 3.533

Review 9.  Modulation of synaptic plasticity by stress and antidepressants.

Authors:  Maurizio Popoli; Massimo Gennarelli; Giorgio Racagni
Journal:  Bipolar Disord       Date:  2002-06       Impact factor: 6.744

10.  Acute treatment with antidepressant drugs selectively increases the expression of c-fos in the rat brain.

Authors:  C H Beck
Journal:  J Psychiatry Neurosci       Date:  1995-01       Impact factor: 6.186
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  5 in total

1.  Analysis of region-specific changes in gene expression upon treatment with citalopram and desipramine reveals temporal dynamics in response to antidepressant drugs at the transcriptome level.

Authors:  Magdalena Gąska; Maciej Kuśmider; Joanna Solich; Agata Faron-Górecka; Małgorzata J Krawczyk; Krzysztof Kułakowski; Marta Dziedzicka-Wasylewska
Journal:  Psychopharmacology (Berl)       Date:  2012-05-01       Impact factor: 4.530

2.  Elastase-2 Knockout Mice Display Anxiogenic- and Antidepressant-Like Phenotype: Putative Role for BDNF Metabolism in Prefrontal Cortex.

Authors:  C R A F Diniz; C Becari; A Lesnikova; C Biojone; M C O Salgado; H C Salgado; L B M Resstel; F S Guimarães; E Castrén; P C Casarotto; S R L Joca
Journal:  Mol Neurobiol       Date:  2018-01-30       Impact factor: 5.590

3.  Theme discovery from gene lists for identification and viewing of multiple functional groups.

Authors:  Petri Pehkonen; Garry Wong; Petri Törönen
Journal:  BMC Bioinformatics       Date:  2005-06-29       Impact factor: 3.169

4.  Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

Authors:  Donald R Staines; Ekua W Brenu; Sonya Marshall-Gradisnik
Journal:  Neuropsychiatr Dis Treat       Date:  2009-04-08       Impact factor: 2.570

5.  Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice.

Authors:  Pawel Lisowski; Grzegorz R Juszczak; Joanna Goscik; Adrian M Stankiewicz; Marek Wieczorek; Lech Zwierzchowski; Artur H Swiergiel
Journal:  BMC Neurosci       Date:  2013-11-13       Impact factor: 3.288
  5 in total

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