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Literature DB >> 15175386

Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs.

Michael C Ashby¹, Sarah A De La Rue, G Scott Ralph, James Uney, Graham L Collingridge, Jeremy M Henley.

Abstract

AMPA receptors (AMPARs) are dynamically regulated at synapses, but the time course and location of their exocytosis and endocytosis are not known. Therefore, we have used ecliptic pHluorin-tagged glutamate receptor 2 to visualize changes in AMPAR surface expression in real time. We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs.

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 15175386 PMCID： PMC3309030 DOI： 10.1523/JNEUROSCI.1042-04.2004

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

21 in total

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Authors: R Malinow; Z F Mainen; Y Hayashi
Journal: Curr Opin Neurobiol Date: 2000-06 Impact factor: 6.627

2. The use of pHluorins for optical measurements of presynaptic activity.

Authors: S Sankaranarayanan; D De Angelis; J E Rothman; T A Ryan
Journal: Biophys J Date: 2000-10 Impact factor: 4.033

3. Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD.

Authors: E C Beattie; R C Carroll; X Yu; W Morishita; H Yasuda; M von Zastrow; R C Malenka
Journal: Nat Neurosci Date: 2000-12 Impact factor: 24.884

4. AMPA receptor trafficking and the control of synaptic transmission.

Authors: M Sheng; S H Lee
Journal: Cell Date: 2001-06-29 Impact factor: 41.582

5. Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons.

Authors: M Passafaro; V Piëch; M Sheng
Journal: Nat Neurosci Date: 2001-09 Impact factor: 24.884

Review 6. pH Homeostasis of cellular organelles.

Authors: Nicolas Demaurex
Journal: News Physiol Sci Date: 2002-02

7. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.

Authors: S Shi; Y Hayashi; J A Esteban; R Malinow
Journal: Cell Date: 2001-05-04 Impact factor: 41.582

Review 8. Role of AMPA receptor endocytosis in synaptic plasticity.

Authors: R C Carroll; E C Beattie; M von Zastrow; R C Malenka
Journal: Nat Rev Neurosci Date: 2001-05 Impact factor: 34.870

9. Regulation of AMPA receptor lateral movements.

Authors: Aren J Borgdorff; Daniel Choquet
Journal: Nature Date: 2002-06-06 Impact factor: 49.962

10. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting.

Authors: M D Ehlers
Journal: Neuron Date: 2000-11 Impact factor: 17.173

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