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Literature DB >> 15175077

IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis.

Abstract

IL-16 is a natural ligand for the CD4 molecule and is known for its chemotactic and anti-HIV-1 activities. We determined IL-16 expression in human brain tissue with HIV-1 encephalitis by specific immunocytochemistry and showed that infiltrating lymphocytes and activated microglia express IL-16. IL-16 immunoreactivity was particularly pronounced in microglial nodules. In vitro, human foetal microglia and not astrocytes produce IL-16, and HIV-1 infection up-regulates microglial IL-16 release in a Nef-dependent manner. These results support the notion that, in the brain, IL-16 is a macrophage-lineage specific modulator of the inflammatory response and HIV-1 expression. Recruitment of IL-16+ T cells and microglia/macrophages may represent an innate response to HIV-1 infection in the central nervous system that counterbalances viral stimulatory factors. Copyright 2003 Blackwell Publishing Ltd

Entities: Disease Gene Species

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Year: 2004 PMID： 15175077 DOI： 10.1046/j.0305-1846.2003.00527.x

Source DB: PubMed Journal: Neuropathol Appl Neurobiol ISSN： 0305-1846 Impact factor: 8.090

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Cited

8 in total

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8. An Investigation into Proteomic Constituents of Cerebrospinal Fluid in Patients with Chronic Peripheral Neuropathic Pain Medicated with Opioids- a Pilot Study.

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8 in total

IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis.

1. CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable.

2. Central nervous system cytokine gene expression: modulation by lead.

3. Human immunodeficiency virus infection inhibits granulocyte-macrophage colony-stimulating factor-induced microglial proliferation.

4. IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages.

Review 5. Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS.

6. CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis.

7. Recent cannabis use in HIV is associated with reduced inflammatory markers in CSF and blood.

8. An Investigation into Proteomic Constituents of Cerebrospinal Fluid in Patients with Chronic Peripheral Neuropathic Pain Medicated with Opioids- a Pilot Study.