Literature DB >> 15174008

Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats.

Mohamad Mroueh1, Yolande Saab, Raed Rizkallah.   

Abstract

The methanol extract of the leaves of Centaurium erythraea L. (Gentianaceae) was evaluated for hepatoprotective activity against acetaminophen-induced liver toxicity in rats. An oral dose of 300 mg/kg/day for 6 days or a single dose of 900 mg/kg for 1 day exhibited a significant protective effect by lowering serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH). The activity of the extract was supported by histopathological examination of liver sections. Copyright 2004 John Wiley & Sons, Ltd.

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Year:  2004        PMID： 15174008     DOI： 10.1002/ptr.1498

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  8 in total

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  8 in total

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