| Literature DB >> 1517289 |
Y Wakui1, E Yanagisawa, E Ishibashi, Y Matsuzaki, S Takeda, H Sasaki, M Aburada, T Oyama.
Abstract
A rapid and sensitive method, using electrochemical detection, has been developed for the determination of baicalin and baicalein, the flavonoid of Scutellariae radix, in rat plasma. Following separation by high-performance liquid chromatography, baicalin and baicalein were oxidized at a glassy carbon electrode to permit selective electrochemical detection. Absolute detection limits were found to be 5 ng/ml from 50 microliters of plasma for baicalin and 2 ng/ml from 100 microliters of plasma for baicalein. The resulting assays were suitable for pharmacokinetic studies of baicalin and baicalein in rats.Entities:
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Year: 1992 PMID： 1517289 DOI： 10.1016/0378-4347(92)80513-p
Source DB: PubMed Journal: J Chromatogr