AIM: To provide basic data for the synthesis of new sinomenine derivatives. METHODS: The C ring in sinomenine was modified. RESULTS: Seven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities. CONCLUSION: Modification of the C ring in sinomenine should be worthy to be studied further.
AIM: To provide basic data for the synthesis of new sinomenine derivatives. METHODS: The C ring in sinomenine was modified. RESULTS: Seven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities. CONCLUSION: Modification of the C ring in sinomenine should be worthy to be studied further.