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Literature DB >> 151716

In vitro growth of cytotoxic human lymphocytes. I. Growth of cells sensitized in vitro to alloantigens.

Abstract

Human lymphocytes sensitized to allogeneic determinants in vitro were continuously cultured on medium prepared from phytohemagglutinin-(PHA-P) stimulated human mixed lymphocyte cultures. With such human-conditioned medium (HCM), human peripheral lymphoid cells could be grown in culture for over 90 days with a doulbing time of about 54 hr. Cytotoxic lymphocytes could be grown in culture for this time with no loss of cytotoxicity or change in cytotoxic specificity.

Entities: Disease Species

Mesh：

Substances：
Culture Media
Isoantigens

Year: 1978 PMID： 151716

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

27 in total

1. Restimulation properties of human alloreactive cloned T-cell lines. Dissection of HLA-D-region alleles in population studies and in family segregation analysis.

Authors: G Pawelec; P Wernet
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

Review 2. Progress in the development of immunotherapy for the treatment of patients with cancer.

Authors: S A Rosenberg
Journal: J Intern Med Date: 2001-12 Impact factor: 8.989

Review 3. IL-2: the first effective immunotherapy for human cancer.

Authors: Steven A Rosenberg
Journal: J Immunol Date: 2014-06-15 Impact factor: 5.422

4. Activation of secondary cytotoxic lymphocytes by cell-free factors from I-region-primed and D-region-primed lymphocytes.

Authors: S Kano; K Oshimi; M Sumiya; N Gonda
Journal: Immunology Date: 1980-11 Impact factor: 7.397

5. A new human pancreatic carcinoma cell line developed for adoptive immunotherapy studies with lymphokine-activated killer cells in nude mice.

Authors: B J Drucker; F M Marincola; D Y Siao; T A Donlon; C D Bangs; W D Holder
Journal: In Vitro Cell Dev Biol Date: 1988-12

6. Specific adoptive immunotherapy of malignant glioma with long-term cytotoxic T lymphocyte line expanded in T-cell growth factor. Experimental study and future prospects.

Authors: T Yamasaki; H Handa; J Yamashita; Y Watanabe; Y Namba; M Hanaoka
Journal: Neurosurg Rev Date: 1984 Impact factor: 3.042

In vitro growth of cytotoxic human lymphocytes. I. Growth of cells sensitized in vitro to alloantigens.

1. Restimulation properties of human alloreactive cloned T-cell lines. Dissection of HLA-D-region alleles in population studies and in family segregation analysis.

Review 2. Progress in the development of immunotherapy for the treatment of patients with cancer.

Review 3. IL-2: the first effective immunotherapy for human cancer.

4. Activation of secondary cytotoxic lymphocytes by cell-free factors from I-region-primed and D-region-primed lymphocytes.

5. A new human pancreatic carcinoma cell line developed for adoptive immunotherapy studies with lymphokine-activated killer cells in nude mice.

6. Specific adoptive immunotherapy of malignant glioma with long-term cytotoxic T lymphocyte line expanded in T-cell growth factor. Experimental study and future prospects.

7. T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor.

8. Human T-cell cultures with selective autotumor reactivity.

9. Bovine T lymphocytes. I. Generation and maintenance of an interleukin-2-dependent, cytotoxic T-lymphocyte cell line.

10. Interleukin 2 activity in peripheral blood mononuclear cells of patients with gynecologic malignancies.