BACKGROUND: Oxidative stress may play an important role in the genesis and development of atherosclerosis. METHODS AND RESULTS: To examine whether oxidative stress is increased in the presence of various coronary risk factors, serum alpha-tocopherol concentrations were determined in 168 apparently healthy subjects recruited from Daioh town (73 men and 95 women, mean age: 42+/-11 years). The alpha-tocopherol concentration (mg/g lipids) was significantly lower in men, older subjects (>or=50 years of age), smokers, those with hyper-low density lipoprotein (LDL)-cholesterolemia (C) (>or=160 mg/dl), hypertriglyceridemia (TG) (>or=150 mg/dl), hypo-high density lipoprotein (HDL)-C (<40 mg/dl), fasting hyperglycemia (>110 mg/dl) and obesity (body mass index >or=25 kg/m (2)) than in women, younger subjects, nonsmokers, those with normoLDL-C, normoTG, normoHDL-C, fasting normoglycemia and the non-obese. The concentration was not significantly different between hypertensives and nonhypertensives. Multivariate logistic regression analysis showed that the adjusted odds ratios (95% confidence interval) for hyperTG and hypoHDL-C as a factor for the lowest tertile of alpha-tocopherol concentration were 6.2 (1.6-24.4, p<0.01) and 6.0 (1.5-22.6, p<0.01), and those of the other risk factors were not significant. The alpha-tocopherol concentrations were significantly positively correlated with HDL-C concentrations (R=0.53) and negatively with TG concentrations (R=-0.53), BMI (R=-0.35), LDL-C concentrations (R=-0.25) and age (R=-0.22). CONCLUSION: Increased oxidative stress, as shown by decreased alpha-tocopherol concentrations, was linked to the presence of various coronary risk factors, among which hyperTG and hypoHDL-C appeared to be most heavily associated with oxidative stress.
BACKGROUND: Oxidative stress may play an important role in the genesis and development of atherosclerosis. METHODS AND RESULTS: To examine whether oxidative stress is increased in the presence of various coronary risk factors, serum alpha-tocopherol concentrations were determined in 168 apparently healthy subjects recruited from Daioh town (73 men and 95 women, mean age: 42+/-11 years). The alpha-tocopherol concentration (mg/g lipids) was significantly lower in men, older subjects (>or=50 years of age), smokers, those with hyper-low density lipoprotein (LDL)-cholesterolemia (C) (>or=160 mg/dl), hypertriglyceridemia (TG) (>or=150 mg/dl), hypo-high density lipoprotein (HDL)-C (<40 mg/dl), fasting hyperglycemia (>110 mg/dl) and obesity (body mass index >or=25 kg/m (2)) than in women, younger subjects, nonsmokers, those with normoLDL-C, normoTG, normoHDL-C, fasting normoglycemia and the non-obese. The concentration was not significantly different between hypertensives and nonhypertensives. Multivariate logistic regression analysis showed that the adjusted odds ratios (95% confidence interval) for hyperTG and hypoHDL-C as a factor for the lowest tertile of alpha-tocopherol concentration were 6.2 (1.6-24.4, p<0.01) and 6.0 (1.5-22.6, p<0.01), and those of the other risk factors were not significant. The alpha-tocopherol concentrations were significantly positively correlated with HDL-C concentrations (R=0.53) and negatively with TG concentrations (R=-0.53), BMI (R=-0.35), LDL-C concentrations (R=-0.25) and age (R=-0.22). CONCLUSION: Increased oxidative stress, as shown by decreased alpha-tocopherol concentrations, was linked to the presence of various coronary risk factors, among which hyperTG and hypoHDL-C appeared to be most heavily associated with oxidative stress.