Literature DB >> 15169617

Awareness in early-stage Alzheimer's disease: a review of methods and evidence.

Linda Clare1.   

Abstract

PURPOSE: This review has three main aims: (1) To illustrate the strengths and limitations of current approaches to assessing awareness of difficulties and impairments in people with early-stage Alzheimer's disease (AD). (2) To consider the evidence regarding factors associated with level of awareness. (3) To highlight the implications for assessment and intervention.
METHODS: A comprehensive range of literature on awareness in AD published in the past 20 years is critically reviewed.
RESULTS: Four main approaches to the assessment of awareness can be discerned, each with significant conceptual and methodological limitations. These limitations affect the quality of the available evidence regarding factors associated with level of awareness, which is contradictory, with few clear findings emerging. Awareness does, however, appear to be related to the outcome of rehabilitation, and this has important implications for the selection of appropriate and sensitive interventions.
CONCLUSIONS: The review highlights the need for a broad conceptualization of awareness. Greater clarity about theoretical frameworks, and improved assessment methods, are required in order to enhance understanding of variations in awareness in early-stage AD. Awareness is an important variable for clinicians to consider.

Entities:  

Mesh:

Year:  2004        PMID: 15169617     DOI: 10.1348/014466504323088042

Source DB:  PubMed          Journal:  Br J Clin Psychol        ISSN: 0144-6657


  28 in total

1.  Alzheimer's disease can spare local metacognition despite global anosognosia: revisiting the confidence-accuracy relationship in episodic memory.

Authors:  David A Gallo; Stefanie J Cramer; Jessica T Wong; David A Bennett
Journal:  Neuropsychologia       Date:  2012-06-18       Impact factor: 3.139

2.  Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment.

Authors:  Feng Lin; Whitney Wharton; N Maritza Dowling; Michele L Ries; Sterling C Johnson; Cynthia M Carlsson; Sanjay Asthana; Carey E Gleason
Journal:  Dement Geriatr Cogn Disord       Date:  2010-08-12       Impact factor: 2.959

3.  Do Subjective Memory Complaints Lead or Follow Objective Cognitive Change? A Five-Year Population Study of Temporal Influence.

Authors:  Beth E Snitz; Brent J Small; Tianxiu Wang; Chung-Chou H Chang; Tiffany F Hughes; Mary Ganguli
Journal:  J Int Neuropsychol Soc       Date:  2015-10       Impact factor: 2.892

Review 4.  Anosognosia in Dementia.

Authors:  Robert S Wilson; Joel Sytsma; Lisa L Barnes; Patricia A Boyle
Journal:  Curr Neurol Neurosci Rep       Date:  2016-09       Impact factor: 5.081

5.  A diagnostic formulation for anosognosia in Alzheimer's disease.

Authors:  S E Starkstein; R Jorge; R Mizrahi; R G Robinson
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-03-20       Impact factor: 10.154

6.  Critical evaluation of self-rated quality of life in mild cognitive impairment and Alzheimer's disease--further evidence for the impact of anosognosia and global cognitive impairment.

Authors:  M Berwig; H Leicht; H J Gertz
Journal:  J Nutr Health Aging       Date:  2009-03       Impact factor: 4.075

7.  Awareness of deficits in financial abilities in patients with mild cognitive impairment: going beyond self-informant discrepancy.

Authors:  Ozioma C Okonkwo; Virginia G Wadley; H Randall Griffith; Katherine Belue; Sara Lanza; Edward Y Zamrini; Lindy E Harrell; John C Brockington; David Clark; Rema Raman; Daniel C Marson
Journal:  Am J Geriatr Psychiatry       Date:  2008-08       Impact factor: 4.105

8.  Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease.

Authors:  Howard J Rosen; Oscar Alcantar; Johannes Rothlind; Virginia Sturm; Joel H Kramer; Michael Weiner; Bruce L Miller
Journal:  Neuroimage       Date:  2009-12-01       Impact factor: 6.556

9.  Standardised measurement of self-awareness deficits in FTD and AD.

Authors:  Craig Williamson; Oscar Alcantar; Johannes Rothlind; Deborah Cahn-Weiner; Bruce L Miller; Howard J Rosen
Journal:  J Neurol Neurosurg Psychiatry       Date:  2009-02-09       Impact factor: 10.154

10.  Development of an awareness-based intervention to enhance quality of life in severe dementia: trial platform.

Authors:  Linda Clare; Robert T Woods; Rhiannon Whitaker; Barbara A Wilson; Murna Downs
Journal:  Trials       Date:  2010-06-25       Impact factor: 2.279

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