Amanda Murchison1, Patrick Duff. 1. Division of Maternal-Fetal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
Abstract
OBJECTIVE: The purpose of this study was to evaluate the effectiveness of misoprostol that is administered intravaginally for uterine evacuation in patients with early pregnancy failures. STUDY DESIGN: From March 2001 through March 2003, we treated 41 patients who had early pregnancy failures with vaginal misoprostol, 800 microg. A second course of misoprostol was administered if uterine evacuation did not occur in 24 hours. Patients who had no response to misoprostol underwent a surgical curettage. Our principal outcome measures were the percentage of patients who had successful evacuation of the products of conception and the frequency of adverse drug effects. RESULTS: Twenty-six patients had successful uterine evacuation with a single course of misoprostol; 6 patients required a second course. The overall success rate was 78% (95% CI, 63, 88). No patient experienced a serious adverse drug effect. CONCLUSION: Intravaginal misoprostol is a safe, effective alternative to surgical curettage for the treatment of early pregnancy failure.
OBJECTIVE: The purpose of this study was to evaluate the effectiveness of misoprostol that is administered intravaginally for uterine evacuation in patients with early pregnancy failures. STUDY DESIGN: From March 2001 through March 2003, we treated 41 patients who had early pregnancy failures with vaginal misoprostol, 800 microg. A second course of misoprostol was administered if uterine evacuation did not occur in 24 hours. Patients who had no response to misoprostol underwent a surgical curettage. Our principal outcome measures were the percentage of patients who had successful evacuation of the products of conception and the frequency of adverse drug effects. RESULTS: Twenty-six patients had successful uterine evacuation with a single course of misoprostol; 6 patients required a second course. The overall success rate was 78% (95% CI, 63, 88). No patient experienced a serious adverse drug effect. CONCLUSION: Intravaginal misoprostol is a safe, effective alternative to surgical curettage for the treatment of early pregnancy failure.
Authors: C Robledo; J Zhang; J Troendle; K Barnhart; M D Creinin; C Westhoff; X Huang; M Frederick Journal: Int J Gynaecol Obstet Date: 2007-06-27 Impact factor: 3.561