PURPOSE: To demonstrate that injection of botulinum toxin type A is less painful when mixed with preserved saline compared with the suggested preservative-free saline reconstitution. METHODS: Two different injections were compared on 20 patients who had prior botulinum toxin type A treatments. Each side was injected with toxin reconstituted with either preserved or nonpreserved (0.9%) saline. The investigators and patients were blinded, and outcome was assessed with a verbal scale. Clinical outcome was subjectively and informally assessed by patient questioning and physician observation. RESULTS: Injection of botulinum toxin type A was noted to be less painful with the use of the preserved compared with the nonpreserved preparation (P<0.0001). The preserved reconstitution appeared to have no effect on clinical outcome. CONCLUSIONS: Injection of botulinum toxin reconstituted with preserved saline is less painful than nonpreserved saline preparations.
RCT Entities:
PURPOSE: To demonstrate that injection of botulinum toxin type A is less painful when mixed with preserved saline compared with the suggested preservative-free saline reconstitution. METHODS: Two different injections were compared on 20 patients who had prior botulinum toxin type A treatments. Each side was injected with toxin reconstituted with either preserved or nonpreserved (0.9%) saline. The investigators and patients were blinded, and outcome was assessed with a verbal scale. Clinical outcome was subjectively and informally assessed by patient questioning and physician observation. RESULTS: Injection of botulinum toxin type A was noted to be less painful with the use of the preserved compared with the nonpreserved preparation (P<0.0001). The preserved reconstitution appeared to have no effect on clinical outcome. CONCLUSIONS: Injection of botulinum toxin reconstituted with preserved saline is less painful than nonpreserved saline preparations.
Authors: Ryan M Dickey; Matthew R Louis; Joshua A Cox; Kriti Mohan; Edward I Lee; Marjory G Nigro Journal: Semin Plast Surg Date: 2016-08 Impact factor: 2.314
Authors: Helka M Heikkilä; Tarja S Jokinen; Pernilla Syrjä; Jouni Junnila; Anna Hielm-Björkman; Outi Laitinen-Vapaavuori Journal: PLoS One Date: 2018-01-10 Impact factor: 3.240