INTRODUCTION: This study examined whether a functional polymorphism (A118G) in the gene encoding the mu-opioid receptor protein, which causes an Asn40Asp substitution in the receptor's extracellular domain, is associated with personality factors, as defined by the Five-Factor Model of Personality. METHODS: Healthy subjects (n=446) and substance-dependent subjects (n=335) underwent a diagnostic interview, completed the NEO Five-Factor Inventory and provided a blood sample for genotyping. Controlling for demographic features and substance dependence diagnosis, analyses examined the allelic association of Asn40Asp with the five personality dimensions. RESULTS: There was no evidence for allelic association with any of the five personality dimensions. CONCLUSION: These findings fail to support the hypothesis that Asn40Asp alleles moderate the development of personality dimensions, as measured by the Five-Factor Model.
INTRODUCTION: This study examined whether a functional polymorphism (A118G) in the gene encoding the mu-opioid receptor protein, which causes an Asn40Asp substitution in the receptor's extracellular domain, is associated with personality factors, as defined by the Five-Factor Model of Personality. METHODS: Healthy subjects (n=446) and substance-dependent subjects (n=335) underwent a diagnostic interview, completed the NEO Five-Factor Inventory and provided a blood sample for genotyping. Controlling for demographic features and substance dependence diagnosis, analyses examined the allelic association of Asn40Asp with the five personality dimensions. RESULTS: There was no evidence for allelic association with any of the five personality dimensions. CONCLUSION: These findings fail to support the hypothesis that Asn40Asp alleles moderate the development of personality dimensions, as measured by the Five-Factor Model.
Authors: Stephen J Glatt; Chad Bousman; Richard S Wang; Kenton K Murthy; Brinda K Rana; Jessica A Lasky-Su; Shao C Zhu; Ruimin Zhang; Jianhua Li; Bo Zhang; Jixiang Li; Michael J Lyons; Stephen V Faraone; Ming T Tsuang Journal: Drug Alcohol Depend Date: 2007-04-09 Impact factor: 4.492
Authors: Jamie A Burns; Danielle S Kroll; Dana E Feldman; Christopher Kure Liu; Peter Manza; Corinde E Wiers; Nora D Volkow; Gene-Jack Wang Journal: Front Psychiatry Date: 2019-09-18 Impact factor: 4.157