BACKGROUND: : Most studies on the effect of alcohol consumption on coronary heart disease or all-cause mortality assess alcohol intake at one point in time and therefore do not take into consideration changes in drinking habits over time. We investigate whether a second assessment of alcohol intake substantially improves estimation of the effects of alcohol intake on these outcomes. DESIGN: : A prospective cohort study of 2710 men and women, age 35-64 years at baseline in 1984/85 in the Augsburg region in southern Germany. We recorded incident fatal and non-fatal coronary events and all-cause mortality until 1997. Alcohol intake and other explanatory variables were assessed in 1984/85 and 1987/88. METHODS: : Based on these assessments, participants were classified as non-drinkers, quitters, starters and constant drinkers. We calculated hazard rate ratios for coronary events and all-cause mortality in these groups and adjusted for several potential confounders using Cox's proportional hazards model. These estimates were compared with hazard rate ratios based on a single assessment of alcohol intake in 1987/88. RESULTS: : Among male constant drinkers the adjusted hazard rate ratio (HRR) for coronary events was lowest among those consuming 0.1-19.9 g alcohol per day, compared with non-drinkers [HRR 0.29; 95% confidence interval (CI) 0.12-0.70]. The lowest all-cause mortality risk was observed among men drinking 20.0-39.9 g per day (HRR 0.48; 95% CI 0.26-0.88). In female constant drinkers the HRR for all-cause mortality was 0.71 (95% CI 0.40-1.26) for those reporting 0.1-19.9 g daily alcohol consumption. Hazard rate ratios for alcohol intake classified by two assessments consistently revealed a more pronounced beneficial effect of alcohol consumption than those for alcohol intake groups based on a single measurement. CONCLUSIONS: : Assessment of alcohol intake at two points in time seems slightly to improve the risk estimation for coronary heart disease (CHD) and for all-cause mortality, compared with a single measurement. Thus, our findings strengthen the evidence of a beneficial effect of light to moderate alcohol consumption on coronary heart disease and all-cause mortality.
RCT Entities:
BACKGROUND: : Most studies on the effect of alcohol consumption on coronary heart disease or all-cause mortality assess alcohol intake at one point in time and therefore do not take into consideration changes in drinking habits over time. We investigate whether a second assessment of alcohol intake substantially improves estimation of the effects of alcohol intake on these outcomes. DESIGN: : A prospective cohort study of 2710 men and women, age 35-64 years at baseline in 1984/85 in the Augsburg region in southern Germany. We recorded incident fatal and non-fatal coronary events and all-cause mortality until 1997. Alcohol intake and other explanatory variables were assessed in 1984/85 and 1987/88. METHODS: : Based on these assessments, participants were classified as non-drinkers, quitters, starters and constant drinkers. We calculated hazard rate ratios for coronary events and all-cause mortality in these groups and adjusted for several potential confounders using Cox's proportional hazards model. These estimates were compared with hazard rate ratios based on a single assessment of alcohol intake in 1987/88. RESULTS: : Among male constant drinkers the adjusted hazard rate ratio (HRR) for coronary events was lowest among those consuming 0.1-19.9 g alcohol per day, compared with non-drinkers [HRR 0.29; 95% confidence interval (CI) 0.12-0.70]. The lowest all-cause mortality risk was observed among men drinking 20.0-39.9 g per day (HRR 0.48; 95% CI 0.26-0.88). In female constant drinkers the HRR for all-cause mortality was 0.71 (95% CI 0.40-1.26) for those reporting 0.1-19.9 g daily alcohol consumption. Hazard rate ratios for alcohol intake classified by two assessments consistently revealed a more pronounced beneficial effect of alcohol consumption than those for alcohol intake groups based on a single measurement. CONCLUSIONS: : Assessment of alcohol intake at two points in time seems slightly to improve the risk estimation for coronary heart disease (CHD) and for all-cause mortality, compared with a single measurement. Thus, our findings strengthen the evidence of a beneficial effect of light to moderate alcohol consumption on coronary heart disease and all-cause mortality.
Authors: C Holzapfel; H Grallert; C Huth; S Wahl; B Fischer; A Döring; I M Rückert; A Hinney; J Hebebrand; H-E Wichmann; H Hauner; T Illig; I M Heid Journal: Int J Obes (Lond) Date: 2010-04-13 Impact factor: 5.095
Authors: Chayakrit Krittanawong; Ameesh Isath; Robert S Rosenson; Muzamil Khawaja; Zhen Wang; Sonya E Fogg; Salim S Virani; Lu Qi; Yin Cao; Michelle T Long; Christy C Tangney; Carl J Lavie Journal: Am J Med Date: 2022-05-14 Impact factor: 5.928
Authors: Manja Koch; Hansjörg Baurecht; Janina S Ried; Elke Rodriguez; Sabrina Schlesinger; Natalie Volks; Christian Gieger; Ina-Maria Rückert; Luise Heinrich; Christina Willenborg; Catherine Smith; Annette Peters; Barbara Thorand; Wolfgang Koenig; Claudia Lamina; Henning Jansen; Florian Kronenberg; Jochen Seissler; Joachim Thiery; Wolfgang Rathmann; Heribert Schunkert; Jeanette Erdmann; Jonathan Barker; Rajan P Nair; Lam C Tsoi; James T Elder; Ulrich Mrowietz; Michael Weichenthal; Sören Mucha; Stefan Schreiber; Andre Franke; Jochen Schmitt; Wolfgang Lieb; Stephan Weidinger Journal: J Invest Dermatol Date: 2015-01-19 Impact factor: 8.551
Authors: Atiqul Haq Mazumder; Jennifer Barnett; Nina Lindberg; Minna Torniainen-Holm; Markku Lähteenvuo; Kaisla Lahdensuo; Martta Kerkelä; Jarmo Hietala; Erkki Tapio Isometsä; Olli Kampman; Tuula Kieseppä; Tuomas Jukuri; Katja Häkkinen; Erik Cederlöf; Willehard Haaki; Risto Kajanne; Asko Wegelius; Teemu Männynsalo; Jussi Niemi-Pynttäri; Kimmo Suokas; Jouko Lönnqvist; Solja Niemelä; Jari Tiihonen; Tiina Paunio; Aarno Palotie; Jaana Suvisaari; Juha Veijola Journal: Brain Sci Date: 2021-05-23