Literature DB >> 1516704

The disulfide bridge pattern of snake venom disintegrins, flavoridin and echistatin.

J J Calvete1, Y Wang, K Mann, W Schäfer, S Niewiarowski, G J Stewart.   

Abstract

Flavoridin and echistatin, isolated from the venom of Trimeresurus flavoviridis and Echis carinatus, respectively, belong to the disintegrin family of integrin beta 1 and beta 3 inhibitors of low molecular weight RGD-containing, cysteine-rich peptides. Since disulfide bonds are critical for expression of biological activity, we sought to determine their location in these two proteins. In flavoridin, direct evidence for the existence of linkage between Cys4-Cys19 and between Cys45 and Cys64 was obtained by analysis of proteolytic products, and indirect evidence suggests links between Cys6-Cys14 and Cys13-Cys36. In echistatin, links between Cys8-Cys37 and Cys20-Cys39 were identified by direct chemical analysis.

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Year:  1992        PMID： 1516704     DOI： 10.1016/0014-5793(92)80797-k

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

1.  The disulfide bond pattern of catrocollastatin C, a disintegrin-like/cysteine-rich protein isolated from Crotalus atrox venom.

Authors:  J J Calvete; M P Moreno-Murciano; L Sanz; M Jürgens; M Schrader; M Raida; D C Benjamin; J W Fox
Journal:  Protein Sci       Date:  2000-07       Impact factor: 6.725

2.  Disulphide-bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin alpha5beta1 antagonist from Eristocophis macmahoni venom.

Authors:  J J Calvete; M Jürgens; C Marcinkiewicz; A Romero; M Schrader; S Niewiarowski
Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

3.  Isolation and Functional Identification of an Antiplatelet RGD-Containing Disintegrin from Cerastes cerastes Venom.

Authors:  Meriem Ameziani; Fatah Chérifi; Hamida Kiheli; Samah Saoud; Ghania Hariti; Safia Kellou-Taîri; Fatima Laraba-Djebari
Journal:  Protein J       Date:  2020-09-22       Impact factor: 2.371

4.  Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.

Authors:  D G Myles; L H Kimmel; C P Blobel; J M White; P Primakoff
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

5.  Immunological characterization of eristostatin and echistatin binding sites on alpha IIb beta 3 and alpha V beta 3 integrins.

Authors:  C Marcinkiewicz; L A Rosenthal; D M Mosser; T J Kunicki; S Niewiarowski
Journal:  Biochem J       Date:  1996-08-01       Impact factor: 3.857

6.  Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa.

Authors:  M Paz Moreno-Murciano; Daniel Monleón; Juan J Calvete; Bernardo Celda; Cezary Marcinkiewicz
Journal:  Protein Sci       Date:  2003-02       Impact factor: 6.725

7.  Differences in binding of (99m)Tc-disintegrins to integrin alphavbeta3 on tumor and vascular cells.

Authors:  Linda C Knight; Jan E Romano; Stephen C Cosenza; Nabisa M Iqbal; Cezary Marcinkiewicz
Journal:  Nucl Med Biol       Date:  2007-05       Impact factor: 2.408

8.  Echistatin disulfide bridges: selective reduction and linkage assignment.

Authors:  W R Gray
Journal:  Protein Sci       Date:  1993-10       Impact factor: 6.725

9.  Three-dimensional structure of echistatin and dynamics of the active site.

Authors:  Y Chen; A K Suri; D Kominos; G Sanyal; A M Naylor; S M Pitzenberger; V M Garsky; R M Levy; J Baum
Journal:  J Biomol NMR       Date:  1994-05       Impact factor: 2.835

10.  Determination of the structure of two novel echistatin variants and comparison of the ability of echistatin variants to inhibit aggregation of platelets from different species.

Authors:  Y L Chen; T F Huang; S W Chen; I H Tsai
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857
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