Literature DB >> 1516612

Verapamil and drug metabolism by the cytochrome P450 isoform CYP1A2.

U Fuhr, B G Woodcock, M Siewert.   

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Year:  1992        PMID： 1516612     DOI： 10.1007/bf00280138

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


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  5 in total

1.  Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Authors:  M A Butler; M Iwasaki; F P Guengerich; F F Kadlubar
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  Verapamil-induced inhibition of theophylline elimination in healthy humans.

Authors:  J E Nielsen-Kudsk; J S Buhl; A C Johannessen
Journal:  Pharmacol Toxicol       Date:  1990-02

3.  Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies.

Authors:  R A Robson; J O Miners; A P Matthews; I Stupans; D Meller; M E McManus; D J Birkett
Journal:  Biochem Pharmacol       Date:  1988-05-01       Impact factor: 5.858

4.  Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes.

Authors:  U Fuhr; T Wolff; S Harder; P Schymanski; A H Staib
Journal:  Drug Metab Dispos       Date:  1990 Nov-Dec       Impact factor: 3.922

5.  Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

Authors:  D Sesardic; A R Boobis; B P Murray; S Murray; J Segura; R de la Torre; D S Davies
Journal:  Br J Clin Pharmacol       Date:  1990-06       Impact factor: 4.335
  5 in total
  7 in total

1.  Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.

Authors:  T S Tracy; K R Korzekwa; F J Gonzalez; I W Wainer
Journal:  Br J Clin Pharmacol       Date:  1999-05       Impact factor: 4.335

Review 2.  Clinically significant pharmacokinetic interactions between dietary caffeine and medications.

Authors:  J A Carrillo; J Benitez
Journal:  Clin Pharmacokinet       Date:  2000-08       Impact factor: 6.447

3.  Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans.

Authors:  D Busse; J Cosme; P Beaune; H K Kroemer; M Eichelbaum
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

4.  Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.

Authors:  U Fuhr; K Klittich; A H Staib
Journal:  Br J Clin Pharmacol       Date:  1993-04       Impact factor: 4.335

5.  Identification of P450 enzymes involved in metabolism of verapamil in humans.

Authors:  H K Kroemer; J C Gautier; P Beaune; C Henderson; C R Wolf; M Eichelbaum
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-09       Impact factor: 3.000

Review 6.  Drug-Drug Interactions Involving Intestinal and Hepatic CYP1A Enzymes.

Authors:  Florian Klomp; Christoph Wenzel; Marek Drozdzik; Stefan Oswald
Journal:  Pharmaceutics       Date:  2020-12-11       Impact factor: 6.321

7.  Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells.

Authors:  Radim Vrzal; Katrin Frauenstein; Peter Proksch; Josef Abel; Zdenek Dvorak; Thomas Haarmann-Stemmann
Journal:  PLoS One       Date:  2013-09-19       Impact factor: 3.240
  7 in total

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