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Literature DB >> 15165905

Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain.

Joanna Dzwonek¹, Marcin Rylski, Leszek Kaczmarek.

Abstract

More than 20 matrix metalloproteinases (MMPs) and four of their endogenous tissue inhibitors (TIMPs) act together to control tightly temporally restricted, focal proteolysis of extracellular matrix. In the neurons of the adult brain several components of the TIMP/MMP system are expressed and are responsive to changes in neuronal activity. Furthermore, functional studies, especially involving blocking of MMP activities, along with the identification of MMP substrates in the brain strongly suggest that this enzymatic system plays an important physiological role in adult brain neurons, possibly being pivotal for neuronal plasticity.

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Year: 2004 PMID： 15165905 DOI： 10.1016/j.febslet.2004.03.070

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

71 in total

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Review 2. The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle.

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3. Methamphetamine and HIV-1 gp120 effects on lipopolysaccharide stimulated matrix metalloproteinase-9 production by human monocyte-derived macrophages.

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Review 4. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction.

Authors: Alexander C W Smith; Michael D Scofield; Peter W Kalivas
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5. Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference.

Authors: Travis E Brown; Melissa R Forquer; Davelle L Cocking; Heiko T Jansen; Joseph W Harding; Barbara A Sorg
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Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain.

Review 1. Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?

Review 2. The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle.

3. Methamphetamine and HIV-1 gp120 effects on lipopolysaccharide stimulated matrix metalloproteinase-9 production by human monocyte-derived macrophages.

Review 4. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction.

5. Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference.

6. Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s).

7. Inhibition of matrix metalloproteinase activity disrupts reconsolidation but not consolidation of a fear memory.

8. Upregulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells.

9. Mmp-9, a potential target for cerebral ischemic treatment.

10. Differential expression patterns of occ1-related genes in adult monkey visual cortex.