| Literature DB >> 15165668 |
Kaoru Miyazaki1, Naoko Narita, Ryoichi Sakuta, Tomoko Miyahara, Hiroshi Naruse, Nobuo Okado, Masaaki Narita.
Abstract
To evaluate the availability of the serum neurotrophins for the diagnosis of the patients with neurodevelopmental disorder, we measured the serum concentration of brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) in the patients diagnosed with autism (n=18) and mental retardation (n=20), or healthy controls (n=16), using enzyme-linked immunosorbent assay. There tended to be a higher concentration of serum BDNF found in the autistic group ( P <0.05 by analysis of variance (ANOVA)) and the mental retardation group ( P <0.001 by ANOVA) compared to the control group. Serum NT-4 concentration tended to be increased in the mental retardation group (P <0.05 by ANOVA). We conclude that measuring the serum concentration of two neurotrophins, BDNF and NT-4, might be helpful to diagnose or classify disorders such as autism or mental retardation.Entities:
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Year: 2004 PMID： 15165668 DOI： 10.1016/S0387-7604(03)00168-2
Source DB: PubMed Journal: Brain Dev ISSN： 0387-7604 Impact factor: 1.961