| Literature DB >> 15165164 |
Claudio Viegas1, Vanderlan da S Bolzani, Maysa Furlan, Eliezer J Barreiro, Maria Claudia M Young, Daniela Tomazela, Marcos N Eberlin.
Abstract
The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay.Entities:
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Year: 2004 PMID： 15165164 DOI： 10.1021/np0303963
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050