Literature DB >> 15165150

Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata.

Vincent Dumontet1, Nguyen Van Hung, Marie-Thérèse Adeline, Claude Riche, Angèle Chiaroni, Thierry Sévenet, Françoise Guéritte.   

Abstract

One alpha-pyrone, obolactone (1), two chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic interpretations. The absolute configuration of obolactone (1) was established by circular dichroism. Obolactone (1) and obochalcolactone (3) display significant activity in in vitro cytotoxic assays against the KB cell line. Biosynthetic pathways for oboflavanones and obochalcolactone are suggested.

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Year:  2004        PMID： 15165150     DOI： 10.1021/np030510h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Authors:  Fumika Tsurumi; Yuta Miura; Yohei Saito; Katsunori Miyake; Tetsuo Fujie; David J Newman; Barry R O'Keefe; Kuo-Hsiung Lee; Kyoko Nakagawa-Goto
Journal:  Org Lett       Date:  2018-04-06       Impact factor: 6.005

2.  Biomimetic Approach to the Catalytic Enantioselective Synthesis of Flavonoids.

Authors:  Zhenyu Yang; Ying He; F Dean Toste
Journal:  J Am Chem Soc       Date:  2016-07-29       Impact factor: 15.419

3.  Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties.

Authors:  Fera Kurniadewi; Lia D Juliawaty; Yana M Syah; Sjamsul A Achmad; Euis H Hakim; Kiyotaka Koyama; Kaoru Kinoshita; Kunio Takahashi
Journal:  J Nat Med       Date:  2009-12-11       Impact factor: 2.343

4.  Constituents of an extract of Cryptocarya rubra housed in a repository with cytotoxic and glucose transport inhibitory effects.

Authors:  Yulin Ren; Chunhua Yuan; Yanrong Qian; Hee-Byung Chai; Xiaozhuo Chen; Michael Goetz; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2013-12-17       Impact factor: 4.050

5.  Antiproliferative effects of methanolic extracts of Cryptocarya concinna Hance roots on oral cancer Ca9-22 and CAL 27 cell lines involving apoptosis, ROS induction, and mitochondrial depolarization.

Authors:  Hurng-Wern Huang; Yi-An Chung; Hsun-Shuo Chang; Jen-Yang Tang; Ih-Sheng Chen; Hsueh-Wei Chang
Journal:  ScientificWorldJournal       Date:  2014-10-15

6.  Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage.

Authors:  Hsun-Shuo Chang; Jen-Yang Tang; Ching-Yu Yen; Hurng-Wern Huang; Chang-Yi Wu; Yi-An Chung; Hui-Ru Wang; Ih-Sheng Chen; Ming-Yii Huang; Hsueh-Wei Chang
Journal:  BMC Complement Altern Med       Date:  2016-03-08       Impact factor: 3.659
  6 in total

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