| Literature DB >> 15163761 |
Corinne Barat1, Philippe Gervais, Michel J Tremblay.
Abstract
Human immunodeficiency virus type 1 (HIV-1) replication is regulated by several extracellular signals. We demonstrate that intercellular adhesion molecule 3 (ICAM-3) acts as a costimulating molecule to increase HIV-1 transcription and viral production, a process allowing productive infection of quiescent CD4+ T lymphocytes. The present work suggests an important role for ICAM-3 in HIV-1 replication.Entities:
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Year: 2004 PMID: 15163761 PMCID: PMC416497 DOI: 10.1128/JVI.78.12.6692-6697.2004
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103